Free thyroxine and thyroid-stimulating hormone reference intervals in very low birth weight infants at 3–6 weeks of life with the Beckman Coulter Unicel DxI 800
| Autor: | Xiaoqin Nan, Sherry L. Perkins, Xiaoli Sun, Sarah E. Lawrence, Nick Barrowman, Brigitte Lemyre, JoAnn Harrold |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Male
endocrine system Pediatrics medicine.medical_specialty endocrine system diseases Birth weight Clinical Biochemistry Population Thyrotropin Thyroid-stimulating hormone medicine Humans Infant Very Low Birth Weight education education.field_of_study Obstetrics business.industry Infant Newborn Gestational age Retrospective cohort study General Medicine Reference Standards Confidence interval Thyroxine Low birth weight Female medicine.symptom Thyroid function business hormones hormone substitutes and hormone antagonists |
| Zdroj: | Clinical Biochemistry. 47:16-18 |
| ISSN: | 0009-9120 |
| Popis: | To establish reference intervals for thyroid stimulating hormone (TSH) and free thyroxine (FT4) at 3-6 weeks of age in very low birth weight (VLBW) infants with the Beckman Coulter Unicel DxI 800 by gender, birth weight (BW) and gestational age (GA) subgroups.A 4 year retrospective cohort of 308 VLBW infants (GA=27.9 weeks, BW=992.3g) was studied. All blood samples for TSH and FT4 were analyzed using the modified fTSH2 (TSH) and two-step competitive enzyme immunoassay (FT4). Reference intervals were evaluated according to the most recent Clinical and Laboratory Standards Institute (CLSI) guidelines.The study provides non-parametric 95% reference intervals with associated 90% confidence intervals for FT4 and TSH derived from 308 infants screened at a median of 31 days. The reference intervals for this population are TSH=1.14-11.04 mIU/L and FT4=10.9-21.4 pmol/L. TSH statistically differed according to birth weight (1000 g vs 1000-1499 g) while FT4 differed according to gender and gestational age at time of testing (32 weeks vs ≥ 32 weeks); however, these differences were not clinically significant and a single reference interval for each analyte is reported.The results of this study highlight the importance and complexity of establishing appropriate reference intervals for thyroid function testing for the preterm population. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect