Genes and nerves
| Autor: | Donald F. Newgreen, Tam Dieu, Bruce R. Johnstone |
|---|---|
| Rok vydání: | 2005 |
| Předmět: |
Nervous system
business.industry Anatomy Median nerve Axons Nerve Regeneration Lesion medicine.anatomical_structure Peripheral Nerve Injuries Peripheral nervous system medicine Biological neural network Humans Trauma Nervous System Surgery Nerve Growth Factors Peripheral Nerves medicine.symptom Pathfinding business Neuroscience Process (anatomy) Brachial plexus |
| Zdroj: | Journal of reconstructive microsurgery. 21(3) |
| ISSN: | 0743-684X |
| Popis: | The unpredictability of a brachial plexus graft, a median nerve repair, or a facial-nerve reconstruction is well known. No matter how precise the technical skills, a perfect recovery from a peripheral-nerve lesion is elusive. To resolve this problem, understanding of the normal development of the peripheral nervous system is needed. Presently, the development of the innervation in the upper limb is complex and not fully understood. However, many of the genes involved in this process are now known, and the link between anatomy and genetics is becoming clearer. This short review aims to acquaint the clinical surgeon with some of the main genes. The principal steps in the establishment of neural circuits will be summarized, in particular, the specification and development of neurons and glia, the pathfinding of cells and axons towards their target, and the downstream molecules that control the circuitry of these neurons. |
| Databáze: | OpenAIRE |
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