Risk factors associated with immunoprophylaxis failure against mother to child transmission of hepatitis B virus and hepatitis B vaccination status in Yunnan province, China
| Autor: | Shuo Zhang, Shuang Zhang, Wenyu Kang, Guofei Huang, Zhengrong Ding, Feng Wang, Zhixian Zhao, Qing Xiong, Liping Shen, Jie Zhang |
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| Rok vydání: | 2013 |
| Předmět: |
HBsAg
Pediatrics medicine.medical_specialty China Birth weight Immunoglobulins medicine.disease_cause Pregnancy Risk Factors medicine Humans Hepatitis B Vaccines Hepatitis B e Antigens Risk factor Pregnancy Complications Infectious Hepatitis B virus Hepatitis B immune globulin Hepatitis B Surface Antigens General Veterinary General Immunology and Microbiology business.industry Transmission (medicine) Public Health Environmental and Occupational Health Infant Newborn virus diseases Hepatitis B Virology digestive system diseases Infectious Disease Transmission Vertical Vaccination Infectious Diseases HBeAg DNA Viral Molecular Medicine Female business medicine.drug |
| Zdroj: | Vaccine. 32(27) |
| ISSN: | 1873-2518 |
| Popis: | Objective To explore the risk factors associated with immunoprophylaxis failure against mother to child transmission of hepatitis B virus (HBV) and hepatitis B vaccination status in Yunnan province, China. Methods Multicenter cluster sampling was used to select pregnant women who were positive for hepatitis B surface antigen (HBsAg). HBV immunoprophylaxis was carried out for the newborns. Blood samples were collected and tested for HBV markers from 7 to 10 month old infants. The factors were analyzed by univariate and logistic regression. Results A total of 2765 mothers and their infants were enrolled. The failure rate of prevention of mother to child transmission (PMTCT) was 4.12%. The rate of timely HepB1 vaccination within 24 h was 98.04%, the rate of three-dose vaccination was 92.30% and the rate of hepatitis B immune globulin (HBIG) administration was 68.97%. Place of residence, maternal education, gestational age and birth weight were related to administration of HBV immunoprophylaxis. It was remarkable that the rate of HBIG administration of infants was only 63.89% with whose mothers were both HBsAg and hepatitis B e antigen (HBeAg)-positive. Further analysis showed that there were three risk factors associated with HBV immunoprophylaxis failure: mothers who were positive for HBsAg and HBeAg, maternal HBVDNA level, and HBIG administration or not. Conclusions PMTCT of HBV was well implemented in Yunnan. However, in order to achieve optimal prevention of vertical HBV transmission, it is mandatory to make additional efforts to improve the implementation of regulatory HBV immunoprophylaxis, especially for HBsAg-positive pregnant women. |
| Databáze: | OpenAIRE |
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