High strength polyvinyl alcohol/polyacrylic acid (PVA/PAA) hydrogel fabricated by Cold-Drawn method for cartilage tissue substitutes
| Autor: | Yinchun Hu, Di Huang, Weiyi Chen, Yan Wei, Weiwei Lan, Mengjie Xu, Miao Qin, Yizhu Cheng |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Vinyl alcohol
0206 medical engineering High water content Acrylic Resins Biomedical Engineering Biophysics Biocompatible Materials Bioengineering macromolecular substances 02 engineering and technology Polyvinyl alcohol Biomaterials chemistry.chemical_compound medicine integumentary system Cartilage Polyacrylic acid technology industry and agriculture Hydrogels 021001 nanoscience & nanotechnology 020601 biomedical engineering medicine.anatomical_structure Chemical engineering chemistry Polyvinyl Alcohol 0210 nano-technology |
| Zdroj: | Journal of Biomaterials Science, Polymer Edition. 31:1836-1851 |
| ISSN: | 1568-5624 0920-5063 |
| DOI: | 10.1080/09205063.2020.1782023 |
| Popis: | Poly (vinyl alcohol) (PVA) hydrogel has been considered as promising cartilage replacement materials due to its excellent characteristics such as high water content, low frictional behavior and excellent biocompatibility. However, lack of sufficient mechanical properties and cytocompatibility are two key obstacles for PVA hydrogel to be applied as cartilage substitutes. Herein, Polyacrylic acid (PAA) has been introduced into PVA hydrogel to balance these problems. Compared with pure PVA hydrogel, PVA/PAA hydrogel has the equal excellent biocompatibility, and its cell adhesion is significantly improved. In order to further improve the mechanical properties of hydrogels, Cold-Drawn treatment of hydrogels is performed in this paper. Compared to pure 12% PVA hydrogel, 40.8-fold, 50.8-fold, and 46.8-fold increase in tensile strength, tensile modulus, and toughness, respectively, which can be obtained from 12% PVA/PAA Cold-Drawn hydrogel. These biocompatible composite hydrogels have a great application potential as cartilage tissue substitutes. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
| Nepřihlášeným uživatelům se plný text nezobrazuje | K zobrazení výsledku je třeba se přihlásit. |