Endurance training-induced changes in the insulin response to oral glucose are associated with the peroxisome proliferator-activated receptor-gamma2 Pro12Ala genotype in men but not in women
| Autor: | Dana A. Phares, Ioana A. Ghiu, Christopher R. Wohn, Onanong Kulaputana, Alan R. Shuldiner, Edward P. Weiss, Josef Brandauer, James M. Hagberg |
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| Rok vydání: | 2004 |
| Předmět: |
Male
medicine.medical_specialty Genotype Endocrinology Diabetes and Metabolism medicine.medical_treatment Peroxisome proliferator-activated receptor Physical exercise Body Mass Index Endocrinology Oxygen Consumption Endurance training Internal medicine Insulin Secretion medicine Humans Insulin Exercise Pancreatic hormone Aged chemistry.chemical_classification Glucose tolerance test Sex Characteristics medicine.diagnostic_test business.industry Area under the curve Glucose Tolerance Test Middle Aged PPAR gamma Glucose chemistry Physical Endurance Female business Body mass index |
| Zdroj: | Metabolism: clinical and experimental. 54(1) |
| ISSN: | 0026-0495 |
| Popis: | The present study sought to investigate, in sedentary men and women, (a) whether a common functional gene variant (peroxisome proliferator-activated receptor-gamma2 [PPARgamma2] Pro12Ala) predicts insulin action and (b) whether improvements in insulin action in response to endurance exercise training are associated with PPARgamma2 Pro12Ala. Sedentary, 50- to 75-year-old men and women (N = 73) were genotyped and underwent oral glucose tolerance tests (OGTTs) before and after 6 months of endurance training. At baseline, men heterozygous for the Pro12Ala variant had a greater OGTT insulin area under the curve (AUC) as compared with Pro12 homozygous men (P = .009). Endurance training resulted in a significantly greater improvement in insulin AUC in Pro12Ala heterozygous men as compared with Pro12 homozygous men (P = .003) despite no genotype-specific differences with respect to training-induced changes in body weight, body mass index, and percent body fat. No differences between genotype groups were present at baseline or in response to training in women. Training did not alter the OGTT glucose AUC for the group as a whole, and the baseline, final, and change in glucose AUC were not dependent on PPARgamma2 genotype and/or sex. In conclusion, these findings suggest that sedentary men with the PPARgamma2 Pro12Ala variant have lower insulin action on glucose disposal as compared with their counterparts. However, these men are particularly responsive with respect to the magnitude of endurance training-induced improvement in insulin action. |
| Databáze: | OpenAIRE |
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