Concomitant treatment with sertraline and social skills training improves social skills acquisition in social anxiety disorder: A double-blind, randomized controlled trial

Autor: Tito Paes de Barros Neto, Mariangela Gentil Savoia, Francisco Lotufo Neto, Cristiane Pinheiro, Márcio Bernik, Fábio Corregiari
Jazyk: angličtina
Rok vydání: 2018
Předmět:
Male
Social Sciences
lcsh:Medicine
Biochemistry
Gastroenterology
law.invention
0302 clinical medicine
Randomized controlled trial
law
Sertraline
Medicine and Health Sciences
Psychology
lcsh:Science
Multidisciplinary
Depression
Pharmaceutics
Social anxiety
Neurochemistry
Neurotransmitters
Middle Aged
Combined Modality Therapy
Anxiety Disorders
Treatment Outcome
Psychotherapy
Group
Anxiety
Female
medicine.symptom
Selective Serotonin Reuptake Inhibitors
Research Article
Social Anxiety Disorder
medicine.drug
Adult
Biogenic Amines
Serotonin
medicine.medical_specialty
Neuropsychiatric Disorders
Neuroses
Placebo
Social Skills
Double blind
Young Adult
03 medical and health sciences
Double-Blind Method
Drug Therapy
Internal medicine
Mental Health and Psychiatry
Drug Psychotherapy
medicine
Humans
Trial registration
Cognitive Behavioral Therapy
Mood Disorders
business.industry
lcsh:R
Cognitive Psychology
Biology and Life Sciences
Phobia
Social
030227 psychiatry
Psychotherapy
Concomitant
Cognitive Science
lcsh:Q
business
Mental Health Therapies
030217 neurology & neurosurgery
Neuroscience
Zdroj: PLoS ONE, Vol 13, Iss 10, p e0205809 (2018)
PLoS ONE
ISSN: 1932-6203
Popis: Objectives To examine whether: (1) sertraline (SER) + psychotherapy is superior to psychotherapy alone; (2) group cognitive-behavioural therapy (GCBT) is superior to group psychodynamic therapy (GPT) and (3) SER+GCBT or SER+GPT is superior to Placebo (PLA)+GCBT or PLA+GPT in social anxiety disorder (SAD). Methods A double-blind randomized controlled trial. Participants were assigned either to: SER+GCBT (n = 34); SER+GPT (n = 36); PLA+GCBT (n = 36) or PLA+GPT (n = 41) for 20 weeks. SER (or PLA) was administered at doses from 50 to 200 mg/d. Primary measures were both categorial: remission (CGI score≤2), response of social symptoms (≥50% reduction in Scale of Avoidance and Social Discomfort (SASD)); and continuous: reduction of SASD and Multidimensional Scale of Social Expression(M-MSSE). Results SER exhibited better improvement of social anxiety symptoms rate than PLA (25.73% vs. 9.46%, P < .05). Neither GCBT differed from GPT (12.33% vs. 22.54%, P = .11) nor SER+GCBT from PLA+GCBT (17.65% vs. 7.69%, P = .20). However, SER+GPT was superior to PLA+GPT (33.33%, vs. 11.43%, P < .05). M-MSSE had superior improvement for SER+GCBT vs PLA+GCBT (P < .01) but not for SER+GPT vs. PLA+GPT (P = .80). SASD scores improvement were greater for SER than PLA (P < .01) and for SER+GCBT vs. PLA+GCBT (P < .05), but neither GCBT differed from GPT(P = .60) nor SER+GPT differed from PLA+GPT (P = .09). Conclusions In overall, SER+psychotherapy was superior to psychotherapy alone. SER potentiated GCBT by enhancing social skills acquisition. Trial registration ISRCTN 57551461.
Databáze: OpenAIRE
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