Intratumoral temozolomide in spontaneous canine gliomas: feasibility of a novel therapy using implanted microcylinders
| Autor: | Shannon P. Holmes, Christine Senneca, Elizabeth W. Howerth, Jill A Hicks, Jared Kaplan, Simon R. Platt, Edward Kaplan, Georgina V. Stewart, Marc Kent |
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| Rok vydání: | 2018 |
| Předmět: |
Male
Canine brain medicine.medical_specialty 040301 veterinary sciences medicine.medical_treatment canine chemotherapy 0403 veterinary science 03 medical and health sciences 0302 clinical medicine Dogs Glioma Temozolomide Medicine Animals magnetic resonance imaging Dog Diseases Antineoplastic Agents Alkylating Craniotomy Drug Implants Chemotherapy lcsh:Veterinary medicine General Veterinary medicine.diagnostic_test business.industry Brain Neoplasms Magnetic resonance imaging 04 agricultural and veterinary sciences Original Articles medicine.disease entotherapy lcsh:SF600-1100 Female Original Article Oligodendroglioma Radiology business 030217 neurology & neurosurgery medicine.drug Glioblastoma |
| Zdroj: | Veterinary Medicine and Science Veterinary Medicine and Science, Vol 5, Iss 1, Pp 5-18 (2019) |
| ISSN: | 2053-1095 |
| Popis: | Entotherapy[Link] an image‐guided drug‐eluting microcylinder platform, has the potential to bypass the limitations of systemic chemotherapy use in the treatment of canine brain tumours. Gliomas, which are common in dogs and also represent the majority of fatal brain tumours in humans, can be amenable to chemotherapy with temozolomide. Biopolymer microcylinders conjugated with temozolomide and gadolinium were implanted into partially resected tumours of four client‐owned dogs with gliomas. All four dogs presented with generalized seizures and had mild to no neurologic deficits at the time of craniotomy. All dogs underwent craniotomy for implantation of the microcylinders into partially resected gliomas (glioblastoma multiforme {n = 1} or oligodendroglioma {n = 3}). All dogs recovered well from the craniotomy and implantation procedure. This novel procedure appears to be feasible and tolerated in tumour‐bearing dogs. A future controlled clinical study can now aim to evaluate the microcylinder implantation for long‐term efficacy. |
| Databáze: | OpenAIRE |
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