Multiple incidence of the prescription diuretic hydrochlorothiazide in compounded nutritional supplements
| Autor: | Emanuele Roselli, Salvatore Scrivano, Roberto Pertile, Fabio Mattiazzi, S. Visentin, Donata Favretto, Susanna Vogliardi, Marianna Tucci, Massimo Montisci |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Dose adverse analytical finding contamination doping hydrochlorothiazide nutritional supplements Chromatography Liquid Dietary Supplements Diuretics Doping in Sports Healthy Volunteers Humans Hydrochlorothiazide Legislation Drug Liquid-Liquid Extraction Powders Substance Abuse Detection Tandem Mass Spectrometry Drug Contamination Urinary system medicine.medical_treatment Legislation Pharmaceutical Science Physiology Urine 01 natural sciences Analytical Chemistry 03 medical and health sciences 0302 clinical medicine medicine Environmental Chemistry Ingestion 030216 legal & forensic medicine Medical prescription Spectroscopy Chromatography Liquid business.industry Incidence (epidemiology) 010401 analytical chemistry 0104 chemical sciences Drug Diuretic business medicine.drug |
| Zdroj: | Drug Testing and Analysis. 11:512-522 |
| ISSN: | 1942-7611 1942-7603 |
| DOI: | 10.1002/dta.2499 |
| Popis: | Diuretic agents are prohibited in sports in- and out-of-competition according to the regulations of the World Anti-Doping Agency (WADA) because of their possible masking effects on other doping agents in urine samples, and their ability to produce fast acute weight losses. Despite previous studies reported adverse analytical findings (AAFs) resulting from contaminations at ppm level (μg/g) of medicinal products, and recommended to introduce reporting limits for diuretics in doping controls, these are not adopted in analyses performed by WADA-accredited laboratories. We report the case of an athlete with two AAFs for hydrochlorothiazide (HCTZ) at low urinary concentrations ( |
| Databáze: | OpenAIRE |
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