Significant Reduction in Breast Cancer Risk for Japanese Women with Interleukin 1B -31 CT/TT Relative to CC Genotype
Autor: | Hiroji Iwata, Katashi Okuma, Lucy S. Ito, Kazuo Tajima, Keitaro Matsuo, Takuji Iwase, Kaoru Hirose, Shigeto Miura, Toshiko Saito, Mitsuhiro Mizutani, Manami Inoue, Nobuyuki Hamajima |
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Rok vydání: | 2002 |
Předmět: |
Adult
Risk Oncology Cancer Research medicine.medical_specialty Genotype Breast surgery medicine.medical_treatment Estrogen receptor Breast Neoplasms Subgroup analysis Minisatellite Repeats Breast cancer Internal medicine Odds Ratio Humans Medicine Radiology Nuclear Medicine and imaging Aged Gynecology Polymorphism Genetic business.industry General Medicine Odds ratio Middle Aged medicine.disease Confidence interval Postmenopause Variable number tandem repeat Premenopause Case-Control Studies Female business Interleukin-1 |
Zdroj: | Japanese Journal of Clinical Oncology. 32:398-402 |
ISSN: | 1465-3621 |
Popis: | Objective: The present case-control study aimed to examine the associations between breast cancer risk and three functional polymorphisms (Interleukin (IL) –1A C-889T, IL-1B C-31T and IL-1RN 86-bp variable number tandem repeat) related to expression of IL-1, which combines estrogen receptor. Methods: Cases were 231 patients with breast cancer who had been diagnosed 1 month to 6 years before their enrollment in 1999–2000 at Aichi Cancer Center Hospital. Controls were 186 non-cancer outpatients recruited during the same period at the digestive tract, breast surgery and gynecology clinics. Results: There were no differences in the genotype distributions of the IL-1A and IL-1RN polymorphisms, but individuals harboring a IL-1B C-31T T allele (high expression allele) were less frequent among cases (74.3%) than among controls (84.9%). The age-adjusted odds ratio (OR) relative to CC genotype was 0.52 (95% confidence interval, 0.30–0.88) for CT genotype, 0.58 (0.32–1.02) for TT genotype and 0.54 (0.33–0.90) for CT/TT genotype. Subgroup analysis showed that the preventive effect was significantly stronger for postmenopausal women than for premenopausal women (interaction 0.30, 0.11–0.84). Conclusions: Although this is the first report on the association between breast cancer risk and IL-1B C-31T, the observed association seems plausible in a biological sense. |
Databáze: | OpenAIRE |
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