Significant Reduction in Breast Cancer Risk for Japanese Women with Interleukin 1B -31 CT/TT Relative to CC Genotype

Autor: Hiroji Iwata, Katashi Okuma, Lucy S. Ito, Kazuo Tajima, Keitaro Matsuo, Takuji Iwase, Kaoru Hirose, Shigeto Miura, Toshiko Saito, Mitsuhiro Mizutani, Manami Inoue, Nobuyuki Hamajima
Rok vydání: 2002
Předmět:
Zdroj: Japanese Journal of Clinical Oncology. 32:398-402
ISSN: 1465-3621
Popis: Objective: The present case-control study aimed to examine the associations between breast cancer risk and three functional polymorphisms (Interleukin (IL) –1A C-889T, IL-1B C-31T and IL-1RN 86-bp variable number tandem repeat) related to expression of IL-1, which combines estrogen receptor. Methods: Cases were 231 patients with breast cancer who had been diagnosed 1 month to 6 years before their enrollment in 1999–2000 at Aichi Cancer Center Hospital. Controls were 186 non-cancer outpatients recruited during the same period at the digestive tract, breast surgery and gynecology clinics. Results: There were no differences in the genotype distributions of the IL-1A and IL-1RN polymorphisms, but individuals harboring a IL-1B C-31T T allele (high expression allele) were less frequent among cases (74.3%) than among controls (84.9%). The age-adjusted odds ratio (OR) relative to CC genotype was 0.52 (95% confidence interval, 0.30–0.88) for CT genotype, 0.58 (0.32–1.02) for TT genotype and 0.54 (0.33–0.90) for CT/TT genotype. Subgroup analysis showed that the preventive effect was significantly stronger for postmenopausal women than for premenopausal women (interaction 0.30, 0.11–0.84). Conclusions: Although this is the first report on the association between breast cancer risk and IL-1B C-31T, the observed association seems plausible in a biological sense.
Databáze: OpenAIRE