Coronary changes in the Atlantic salmonSalmo salarL: characterization and impact of dietary fatty acid compositions
| Autor: | Bente E. Torstensen, Erling Olaf Koppang, Randi Tangen, Grethe Rosenlund, Ivar Hordvik, Alf Seljenes Dalum, Knut Falk |
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| Rok vydání: | 2014 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Veterinary (miscellaneous) Salmo salar Coronary Artery Disease Aquatic Science Extracellular matrix Pathogenesis Fish Diseases 03 medical and health sciences Microscopy Electron Transmission Neointima Internal medicine medicine Animals Salmo Gene chemistry.chemical_classification biology Myocardium Fatty Acids Fatty acid Lipid metabolism Gene Expression Regulation Bacterial Arteriosclerosis biology.organism_classification medicine.disease Coronary Vessels Dietary Fats Immunohistochemistry Diet Extracellular Matrix Up-Regulation Coronary arteries 030104 developmental biology Endocrinology medicine.anatomical_structure chemistry Biochemistry Microscopy Electron Scanning |
| Zdroj: | Journal of Fish Diseases. 39:41-54 |
| ISSN: | 0140-7775 |
| Popis: | Consumption of fatty acids from fishes is widely regarded as beneficial for preventing cardiovascular disorders. Nevertheless, salmonids themselves are victims of vascular diseases. As the pathogenesis and nature of these changes are elusive, they are here addressed using novel morphological and transcriptional approaches. Coronary arteries of wild Atlantic salmon Salmo salar L., (n = 12) were investigated using histological and immunohistochemical techniques, and RT-qPCR was employed to investigate expression of stretch-induced genes. In an experimental trial, fish were fed diets with different fatty acids composition, and histological features of the coronary arteries (n = 36) were investigated. In addition, the heart fatty acid profile (n = 60) was analysed. There were no differences in morphological or immunological features between wild fish and groups of experimental fish. Arteriosclerotic lesions consisted of smooth muscle cells in dissimilar differential stages embedded in considerable amounts of extracellular matrix in a similar fashion to what is seen in early stages of human atherosclerosis. No fat accumulations were observed, and very few inflammatory cells were present. In affected arteries, there was an induction of stretch-related genes, pointing to a stress-related response. We suggest that salmon may have a natural resistance to developing atherosclerosis, which corresponds well with their high investment in lipid metabolism. |
| Databáze: | OpenAIRE |
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