Active Sites in Stereoselective Adsorbents as Models of Drug Receptors and Enzyme Active Sites

Autor:	A. H. Beckett, H. Z. Youssef
Rok vydání:	1963
Předmět:	Pharmacology chemistry.chemical_classification Quinine Chemistry Pharmaceutical Receptors Drug Research Sodium Inorganic chemistry Pharmaceutical Science chemistry.chemical_element Pharmacy Enzyme Adsorption chemistry Catalytic Domain Acridines Organic chemistry Stereoselectivity Selectivity
Zdroj:	Journal of Pharmacy and Pharmacology. 15:253T-266T
ISSN:	2042-7158 0022-3573
DOI:	10.1111/j.2042-7158.1963.tb11220.x
Popis:	The treatment of quinine-selective adsorbents by steam, heat, in presence of water and by treatment with acid and dry organic solvents destroyed their selectivity whereas the adsorptive power of control adsorbents was almost unaffected by these treatments. A progressive increase in pH of the adsorbate solutions from pH 1 to 3 increased the adsorptive power of the selective adsorbents more than that of the control adsorbents. Increasing concentrations of sodium chloride in the adsorbate solutions increased the quinine-uptake on the adsorbents. Stereoselectivity is probably due to the formation of “footprints” in the surface of selective adsorbents. The similarities between the behaviour of active sites in biological surfaces and those in these stereoselective adsorbents are described.
Databáze:	OpenAIRE
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