Endodontic set sealer eluates promote cytokine production in human mononuclear and periodontal ligament cells
| Autor: | Rubén Abraham Domínguez-Pérez, Ofelia Mora-Izaguirre, Rosa Martha Pérez-Serrano, Ana I Soza-Bolaños, Till Dammaschke, Samantha N Castillo-Valdés, Gabriela Hernández-Valdez, María L. González‐Dávalos |
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| Rok vydání: | 2021 |
| Předmět: |
Necrosis
Periodontal Ligament Chemistry medicine.medical_treatment 0206 medical engineering 030206 dentistry 02 engineering and technology 020601 biomedical engineering Peripheral blood mononuclear cell Peripheral blood Root Canal Filling Materials Clinical Practice Andrology 03 medical and health sciences 0302 clinical medicine Cytokine MTA-Fillapex Leukocytes Mononuclear medicine Pulp canal Cytokines Humans Periodontal fiber medicine.symptom General Dentistry |
| Zdroj: | Australian Endodontic Journal. 47:415-422 |
| ISSN: | 1747-4477 1329-1947 |
| Popis: | Endodontic freshly mixed sealers display toxic effects; however, these are significantly reduced and most become relatively inert in the set state but there is no information about the possible inflammatory reaction promoted by them. Four contemporary and different formulated endodontic set sealers (MTA Fillapex, BioRoot RCS, AH Plus, and Pulp Canal Sealer) were evaluated. Human periodontal ligament cells and human peripheral blood mononuclear cells were stimulated for 3, 6, 12 and 24 h. Interleukin-6, tumour necrosis factor-alpha, interleukin-8 and interleukin-10 concentrations were measured by enzyme-linked immunosorbent assay. All endodontic set sealer eluates promoted a similar production (P ˃ 0.05) of the four cytokines. However, their concentrations decreased within a short time period to nearly undetectable concentrations after 24 h, suggesting that the studied endodontic set sealers do not possess inflammatory properties which has favoured their long-term use in clinical practice. |
| Databáze: | OpenAIRE |
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