Use of atropine to reduce mucosal eversion during intestinal resection and anastomosis in the dog
| Autor: | Richard Walshaw, Marta D. Agrodnia, Joe Hauptman |
|---|---|
| Rok vydání: | 2003 |
| Předmět: |
Atropine
medicine.medical_specialty medicine.medical_treatment Muscarinic Antagonists Anastomosis Beagle Drug Administration Schedule Injections Jejunum Dogs medicine Animals Single-Blind Method Prospective Studies Intestinal Mucosa Saline General Veterinary business.industry Anastomosis Surgical Suture Techniques Jejunal arteries Arteries Surgery medicine.anatomical_structure Treatment Outcome Anesthesia Premedication Female Intestinal resection business medicine.drug |
| Zdroj: | Veterinary surgery : VS. 32(4) |
| ISSN: | 0161-3499 |
| Popis: | Objective— To determine whether atropine altered the degree of mucosal eversion during jejunal resection and anastomosis in the dog. Study Design— Part I: Prospective, blinded, randomized, controlled study using a therapeutic dose (0.04 mg/kg systemic) of atropine. Part II: Prospective, unblinded, assigned, controlled study using a pharmacologic (0.04 mg/kg local arterial) dose of atropine. Animals— Part I: Twenty-two young adult female Beagle dogs used during a nonsurvival third-year veterinary student surgical laboratory (small intestinal resection and anastomosis). Part II: Ten young adult female Beagle dogs used immediately after completion of a nonsurvival third-year veterinary student orthopedic surgical laboratory. Methods— Part I: Dogs were randomly assigned to receive either atropine (0.04 mg/kg), or an equal volume of saline, given intramuscularly (premedication) and again intravenously prior to intestinal resection. Part II: In each dog, atropine (0.04 mg/kg)/saline was alternately given in the proximal/distal jejunum. Results— Part I: There was no clinically or statistically significant difference between systemic atropine and saline solution on the degree of jejunal mucosal eversion after resection. Part II: There was a statistically significant decrease in jejunal mucosal eversion with atropine compared with saline solution when injected into a local jejunal artery. Conclusion— Systemic atropine (0.04 mg/kg) does not alter the degree of jejunal mucosal eversion during resection and anastomosis. Jejunal intraarterial atropine (0.04 mg/kg) reduced jejunal mucosal eversion during resection and anastomosis. Clinical Relevance— The clinical usefulness and consequences of jejunal arterial atropine administration to reduce mucosal eversion remain to be determined. |
| Databáze: | OpenAIRE |
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