Maternal hepatotoxicity with nevirapine as part of combination antiretroviral therapy in pregnancy
| Autor: | F Lyons, PA McCormick, Gerard Sheehan, Colm Bergin, Fiona Mulcahy, Susan Hopkins, J Geoghegan, A McGeary, B Kelleher |
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| Rok vydání: | 2006 |
| Předmět: |
Adult
Pediatrics medicine.medical_specialty Nevirapine Adolescent Anti-HIV Agents HIV Infections law.invention Zidovudine Randomized controlled trial Acquired immunodeficiency syndrome (AIDS) Pregnancy Risk Factors law medicine Humans Pharmacology (medical) Pregnancy Complications Infectious Retrospective Studies business.industry Health Policy Retrospective cohort study medicine.disease CD4 Lymphocyte Count Pregnancy Complications Infectious Diseases Anti-Retroviral Agents Tolerability Immunology Cohort HIV-1 Drug Therapy Combination Female Chemical and Drug Induced Liver Injury business medicine.drug |
| Zdroj: | Europe PubMed Central |
| ISSN: | 1468-1293 1464-2662 |
| DOI: | 10.1111/j.1468-1293.2006.00369.x |
| Popis: | Objectives To describe the maternal tolerability of nevirapine as part of combination antiretroviral therapy in pregnancy at three HIV centres in Dublin, Ireland and to determine risk factors for development of significant hepatotoxicity. Methods A retrospective study was carried out of all women prescribed nevirapine as part of combination antiretroviral therapy in pregnancy at three HIV centres in Dublin, Ireland (October 2000 to February 2003). Toxicities experienced were graded according to the Division of AIDS toxicity guidelines for adults. Statistical analysis was performed to determine whether there were differences between those that did and those that did not experience significant hepatotoxicity. Results A total of 123 women initiated nevirapine as part of combination antiretroviral therapy in the study period. Eight women developed significant hepatotoxicity, including two women who died from fulminant hepatitis. Women who experienced more severe hepatotoxicity had higher pretreatment CD4 counts (P=0.01). Conclusions In this cohort, women who experienced more severe hepatotoxicity had higher pretreatment CD4 counts, lending additional weight to the need for caution in using nevirapine as part of combination antiretroviral therapy in women not requiring antiretroviral therapy for their own health. |
| Databáze: | OpenAIRE |
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