Erythropoietin Levels and Microcytosis in Heterozygous Beta-Thalassaemia
| Autor: | Konstantinos Konstantopoulos, Y. Rombos, T. Tassiopoulos, V. Alevizou-Terzaki, P. Kyriaki, Dimitris Loukopoulos, Stergios Tassiopoulos |
|---|---|
| Rok vydání: | 1997 |
| Předmět: |
Adult
Hemolytic anemia Heterozygote medicine.medical_specialty Biology hemic and lymphatic diseases Internal medicine parasitic diseases medicine Humans Erythropoietin Anemia Iron-Deficiency Microcytosis beta-Thalassemia Beta thalassemia Heterozygote advantage Hematology General Medicine medicine.disease stomatognathic diseases Red blood cell Endocrinology Hemoglobinopathy medicine.anatomical_structure Iron-deficiency anemia Female geographic locations medicine.drug |
| Zdroj: | Acta Haematologica. 98:147-149 |
| ISSN: | 1421-9662 0001-5792 |
| DOI: | 10.1159/000203609 |
| Popis: | Erythropoietin levels were determined in 50 Greek females: 20 beta-thalassaemia (beta-thal) heterozygotes, 15 with a diagnosis of iron-deficiency anaemia and 15 normal controls. In beta-thal trait carriers, the erythropoietin levels were slightly higher than in normal controls (16.65 +/- 4.43 vs. 12.84 +/- 2.47 mU/ml); these levels were significantly lower than those in iron-deficient subjects with the same degree of anaemia (55.24 +/- 31.35 mU/ml). In both groups, the erythropoietin levels are statistically correlated with the severity of anaemia (r = -0.537 p0.05 for iron deficiency; r = -0.610 p0.01 for beta-thal heterozygotes). In beta-thal heterozygotes, a close inverse correlation with red cell number and erythropoietin levels was also noted. It is suggested that microcytosis accompanying beta-thal trait constitutes an additional factor intervening in the regulation of erythropoiesis. |
| Databáze: | OpenAIRE |
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