Photocatalytic antibacterial application of zinc oxide nanoparticles and self-assembled networks under dual UV irradiation for enhanced disinfection
| Autor: | Jun Eon Jin, Su-Eon Jin, Woochul Hwang, Seok Won Hong |
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| Rok vydání: | 2019 |
| Předmět: |
Silicon
Materials science Ultraviolet Rays Biophysics Pharmaceutical Science Nanoparticle chemistry.chemical_element zinc oxide nanoparticles Bioengineering 02 engineering and technology Zinc Microbial Sensitivity Tests 010402 general chemistry medicine.disease_cause Eye 01 natural sciences Catalysis Cell Line Biomaterials International Journal of Nanomedicine Drug Discovery medicine Escherichia coli Humans Irradiation Particle Size Skin Original Research Organic Chemistry toxicity General Medicine 021001 nanoscience & nanotechnology dual UV 0104 chemical sciences Anti-Bacterial Agents Disinfection HaCaT antibacterial chemistry Nanocrystal immobilization Photocatalysis Nanoparticles Zinc Oxide 0210 nano-technology Antibacterial activity Crystallization Ultraviolet Nuclear chemistry |
| Zdroj: | International Journal of Nanomedicine |
| ISSN: | 1178-2013 |
| Popis: | Su-Eon Jin,1 Jun Eon Jin,2 Woochul Hwang,3 Seok Won Hong4 1Research Institute for Medical Sciences, College of Medicine, Inha University, Incheon 22212, Korea; 2College of Electrical Engineering, Korea University, Seoul 02841, Korea; 3ECOSET Co., Ltd., Ansan 15610, Korea; 4Korea Institute of Science and Technology, Seoul 02792, Korea Background: Zinc oxide (ZnO) nanoparticles and their networks have been developed for use in various applications such as gas sensors and semiconductors. Aim: In this study, their antibacterial activity against Escherichia coli under dual ultraviolet (UV) irradiation for disinfection was investigated. Materials and methods: ZnO nanoparticles were synthesized and immobilized onto silicon (Si) wafers by self-assembly. The physicochemical properties and antibacterial activity of ZnO nanoparticles and their networks were evaluated. Gene ontology was analyzed and toxicity levels were also monitored. Results: Synthesized ZnO nanoparticles were spherical nanocrystals (3log CFU/ml). Specifically, arrayed ZnO nanoparticle networks showed superior activity compared with free synthesized ZnO nanoparticles. Oxidative stress-responsive proteins in E. coli were identified and categorized, which indicated antibacterial activity. Synthesized ZnO nanoparticles were less cytotoxic in HaCaT with an IC50 of 6.632 mg/mL, but phototoxic in Balb/c 3T3. Conclusion: The results suggested that ZnO nanoparticles and their networks can be promising photocatalytic antibiotics for use in next-generation disinfection systems. Their application could also be extended to industrial and clinical use as effective and safe photocatalytic antibiotics. Keywords: zinc oxide nanoparticles, immobilization, dual UV, antibacterial, disinfection, toxicity |
| Databáze: | OpenAIRE |
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