Value of quantitative and qualitative analyses of serum and urine cell-free DNA as diagnostic tools for bladder cancer: a meta-analysis
| Autor: | Liangkuan Bi, Longfei Peng, Ying Zhang, Youlu Lu, Xin Wang, Ke He, Zhangjun Cao |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Oncology medicine.medical_specialty Urine Likelihood ratios in diagnostic testing Sensitivity and Specificity Circulating Tumor DNA 03 medical and health sciences 0302 clinical medicine Internal medicine Medicine Humans Pharmacology (medical) Bladder cancer Receiver operating characteristic business.industry Area under the curve Reproducibility of Results medicine.disease 030104 developmental biology Cell-free fetal DNA Urinary Bladder Neoplasms 030220 oncology & carcinogenesis Meta-analysis Diagnostic odds ratio business |
| Zdroj: | Expert review of anticancer therapy. 19(7) |
| ISSN: | 1744-8328 |
| Popis: | Background: Qualitative and quantitative analysis of circulating cell-free DNA (cfDNA) is a potential detection method for bladder cancer. Many studies have focused on the reliability of these results, but the conclusions have not been consistent. Methods: We performed a diagnostic meta-analysis to investigate the diagnostic significance of serum and urine cfDNAs with tumor tissues as the standard control. We searched the MEDLINE, EMABASE, and Cochrane Central Controlled Trials Register (CCTR) databases until January 2019. Results: A total of 11 studies involving early and/or advanced bladder cancer were finally included. The overall diagnostic accuracy was measured as follows: pooled sensitivity and specifcity were 0.69 (95%CI: 0.67, 0.71) and 0.72 (95%CI: 0.70, 0.74). Pooled positive likelihood ratio and negative likelihood ratio were 3.10 (95%CI: 2.35, 4.07) and 0.41 (95%CI: 0.34, 0.49). Combined diagnostic odds ratio was 8.26 (95%CI: 5.64, 12.11). A high diagnostic accuracy was demonstrated by the summary receiver operating characteristic curve, with area under the curve of 0.80 (95%CI: 0.77, 0.83). Conclusions: CfDNA assay has high diagnostic value for the detection of bladder cancer. Larger sample studies are needed to further confirm our conclusions and to make this approach more sensitive and specific. |
| Databáze: | OpenAIRE |
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