Nasopharyngeal microbiota in healthy children and pneumonia patients
| Autor: | Viktoria Bastic Schmid, Olga Sakwinska, Kristina Keitel, Deborah Moine, Bernard Berger, Harald Brüssow, Catherine Ngom Bru, Alain Gervaix, Anne Bruttin, Mélissa Lepage |
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| Rok vydání: | 2014 |
| Předmět: |
Microbiology (medical)
Haemophilus Infections Adolescent Moraxellaceae Infections Pneumococcal Infections/diagnosis/microbiology medicine.disease_cause Pneumococcal Infections Haemophilus influenzae Microbiology Moraxella catarrhalis Nasopharynx Moraxella (Branhamella) catarrhalis Haemophilus Infections/diagnosis/microbiology Streptococcus pneumoniae medicine Humans Microbiota/genetics Prospective Studies Nasopharynx/microbiology/virology Author Correction Child 610 Medicine & health Respiratory Tract Infections Pneumonia/diagnosis/microbiology/virology Streptococcus pneumoniae/genetics ddc:618 biology Respiratory tract infections Microbiota Infant Moraxellaceae Infections/diagnosis/microbiology Pneumonia Haemophilus influenzae/genetics biology.organism_classification medicine.disease Viral pneumonia Case-Control Studies Child Preschool Immunology Moraxella lacunata Respiratory Tract Infections/diagnosis/microbiology/virology Moraxella (Branhamella) catarrhalis/genetics |
| Zdroj: | Journal of Clinical Microbiology, Vol. 52, No 5 (2014) pp. 1590-1594 |
| ISSN: | 0095-1137 |
| DOI: | 10.48350/160551 |
| Popis: | Our study is the first to compare the nasopharyngeal microbiota of pediatric pneumonia patients and control children by 454 pyrosequencing. A distinct microbiota was associated with different pneumonia etiologies. Viral pneumonia was associated with a high abundance of the operational taxonomic unit (OTU) corresponding to Moraxella lacunata . Patients with nonviral pneumonia showed high abundances of OTUs of three typical bacterial pathogens, Streptococcus pneumoniae complex, Haemophilus influenzae complex, and Moraxella catarrhalis . Patients classified as having no definitive etiology harbored microbiota particularly enriched in the H. influenzae complex. We did not observe a commensal taxon specifically associated with health. The microbiota of the healthy nasopharynx was more diverse and contained a wider range of less abundant taxa. |
| Databáze: | OpenAIRE |
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