Genome-wide patterns of differentiation within and among U.S. commercial honey bee stocks
| Autor: | Arian Avalos, Frank D. Rinkevich, Perot Saelao, Michael Simone-Finstrom, Philip Tokarz, Lelania Bilodeau, Robert G. Danka, Lilia I. de Guzman |
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| Rok vydání: | 2020 |
| Předmět: |
Genetic Markers
0106 biological sciences lcsh:QH426-470 Pool-seq lcsh:Biotechnology Varroidae Population genetics 01 natural sciences Work related Genetic diversity 03 medical and health sciences Pollinator lcsh:TP248.13-248.65 Genetic variation Genetics Animals FST Selection Genetic 030304 developmental biology 0303 health sciences biology Genetic Variation High-Throughput Nucleotide Sequencing Honey bee Bees biology.organism_classification United States Single nucleotide polymorphism lcsh:Genetics 010602 entomology Evolutionary biology Genetic marker Varroa Apis mellifera Stock identification Research Article Biotechnology |
| Zdroj: | BMC Genomics BMC Genomics, Vol 21, Iss 1, Pp 1-12 (2020) |
| ISSN: | 1471-2164 |
| DOI: | 10.1186/s12864-020-07111-x |
| Popis: | Background The population genetics of U.S. honey bee stocks remain poorly characterized despite the agricultural importance of Apis mellifera as the major crop pollinator. Commercial and research-based breeding programs have made significant improvements of favorable genetic traits (e.g. production and disease resistance). The variety of bees produced by artificial selection provides an opportunity to characterize the genetic diversity and regions of the genome undergoing selection in commonly managed stocks. Results Pooled sequencing of eight honey bee stocks found strong genetic similarity among six of the stocks. Two stocks, Pol-line and Hilo, showed significant differentiation likely due to their intense and largely closed breeding for resistance to the parasitic Varroa mite. Few variants were identified as being specific to any one stock, indicating potential admixture among the sequenced stocks. Juxtaposing the underlying genetic variation of stocks selected for disease- and parasite-resistance behavior, we identified genes and candidate regions putatively associated with resistance regulated by hygienic behavior. Conclusion This study provides important insights into the distinct genetic characteristics and population diversity of honey bee stocks used in the United States, and provides further evidence of high levels of admixture in commercially managed honey bee stocks. Furthermore, breeding efforts to enhance parasite resistance in honey bees may have created unique genetic profiles. Genomic regions of interest have been highlighted for potential future work related to developing genetic markers for selection of disease and parasite resistance traits. Due to the vast genomic similarities found among stocks in general, our findings suggest that additional data regarding gene expression, epigenetic and regulatory information are needed to more fully determine how stock phenotypic diversity is regulated. |
| Databáze: | OpenAIRE |
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