The interleukin-1 polymorphism, smoking, and the risk of periodontal disease in the population-based SHIP study
| Autor: | Ulrich John, F.H. Herrmann, P. Meisel, Christian Schwahn, R. Grimm, A. Siegemund, Thomas Kocher |
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| Rok vydání: | 2003 |
| Předmět: |
0301 basic medicine
Adult Male medicine.medical_specialty Genotype Cross-sectional study Population Dentistry Sampling Studies 03 medical and health sciences 0302 clinical medicine Risk Factors Internal medicine Germany Epidemiology Odds Ratio Medicine Humans education Periodontitis General Dentistry education.field_of_study Analysis of Variance Polymorphism Genetic business.industry Smoking 030206 dentistry Odds ratio Middle Aged medicine.disease 030104 developmental biology Cross-Sectional Studies Logistic Models Study of Health in Pomerania Female Risk assessment business Interleukin-1 |
| Zdroj: | Journal of dental research. 82(3) |
| ISSN: | 0022-0345 |
| Popis: | Several studies have shown a role for interleukin-1 gene cluster polymorphisms in the risk assessment for periodontal diseases. In the Study of Health in Pomerania (SHIP), 3148 subjects were randomly selected from the population and assessed for a broad range of diseases and environmental/behavioral risk factors. From the complete study group in the age 40 to 60 years, N = 1085 subjects were genotyped for the interleukin-1 genotype composite polymorphism in relation to periodontal parameters. The study objective was to elucidate the gene-environment interaction between the risk factors smoking and IL-1 polymorphism. An increased risk of periodontal disease was found for IL-1 genotype-positive smokers: odds ratio adjusted for age, sex, education, and plaque OR = 2.50 (95% C.I. 1.21 to 5.13; p = 0.013). This was not the case with subjects who never smoked: OR = 1.09 (0.73-1.62; p = 0.676). These results support the hypothesis of gene-environmental interaction in periodontitis. |
| Databáze: | OpenAIRE |
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