Role of thyroid dysimmunity and thyroid hormones in endometriosis
| Autor: | Niloufar Kavian, Carole Nicco, Sandrine Chouzenoux, Ludivine Doridot, Laurie Toullec, Marine Peyneau, Charles Chapron, Frédéric Batteux, Fernando M. Reis, Pietro Santulli, Jeanne Reboul-Marty, Mohamed Jeljeli, Camille Chenevier-Gobeaux |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty endocrine system Thyroid Hormones endocrine system diseases Endometriosis Thyroid Gland Thyrotropin medicine.disease_cause Autoimmunity 03 medical and health sciences Endometrium Mice 0302 clinical medicine Internal medicine medicine Animals Humans Cell Proliferation Retrospective Studies Mice Inbred BALB C 030219 obstetrics & reproductive medicine Multidisciplinary Triiodothyronine business.industry Pelvic pain Thyroid Biological Sciences medicine.disease Pathophysiology Thyroid disorder Mice Inbred C57BL Thyroxine 030104 developmental biology Endocrinology medicine.anatomical_structure Female medicine.symptom business Reactive Oxygen Species Hormone |
| Zdroj: | Proceedings of the National Academy of Sciences of the United States of America. 116(24) |
| ISSN: | 1091-6490 |
| Popis: | Endometriosis is characterized by the presence of ectopic endometrial cells outside the uterine cavity. Thyroid autoimmunity has been associated with endometriosis. This work investigated the potential pathophysiological link between endometriosis and thyroid disorders. Transcripts and proteins involved in thyroid metabolism are dysregulated in eutopic and ectopic endometrium of endometriotic patients, leading to resistance of ectopic endometrium to triiodothyronine (T3) action and local accumulation of thyroxine (T4). Thyroid-stimulating hormone (TSH) acts as a proliferative and prooxidative hormone on all endometria of endometriosis patients and controls, whereas T3 and T4 act to specifically increase ectopic endometrial cell proliferation and reactive oxygen species (ROS) production. Mouse studies confirmed the data gained in vitro since endometriotic implants were found to be bigger when thyroid hormones increased. A retrospective analysis of endometriosis patients with or without a thyroid disorder revealed an increased chronic pelvic pain and disease score in endometriotic patients with a thyroid disorder. |
| Databáze: | OpenAIRE |
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