Baseline White Matter Hyperintensities and Hippocampal Volume are Associated With Conversion From Normal Cognition to Mild Cognitive Impairment in the Framingham Offspring Study
| Autor: | Charles DeCarli, Sarah R. Preis, Katherine J. Bangen, Mark W. Bondi, Lisa Delano-Wood, Rhoda Au, Philip A. Wolf, Adam M. Brickman, David J. Libon |
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| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine medicine.medical_specialty Neuropsychological Tests Hippocampus behavioral disciplines and activities Article Developmental psychology White matter 03 medical and health sciences Cognition 0302 clinical medicine Internal medicine mental disorders medicine Humans Cognitive Dysfunction Longitudinal Studies Prospective Studies Neuropsychological assessment Aged Framingham Risk Score medicine.diagnostic_test business.industry Neuropsychology Magnetic resonance imaging Magnetic Resonance Imaging White Matter Hyperintensity Psychiatry and Mental health Clinical Psychology Cross-Sectional Studies 030104 developmental biology medicine.anatomical_structure Massachusetts Brain size Cardiology Female Geriatrics and Gerontology business human activities Gerontology 030217 neurology & neurosurgery |
| Zdroj: | Alzheimer Disease & Associated Disorders. 32:50-56 |
| ISSN: | 0893-0341 |
| DOI: | 10.1097/wad.0000000000000215 |
| Popis: | Introduction We examined associations between magnetic resonance imaging (MRI) markers of cerebrovascular disease and neurodegeneration with mild cognitive impairment (MCI) diagnosis at baseline and conversion from normal cognition to MCI at follow-up. Methods Framingham Offspring participants underwent brain MRI and neuropsychological assessment at baseline (n=1049) and follow-up (n=561). Participants were classified at baseline and at follow-up as cognitively normal or MCI using sensitive neuropsychological criteria. White matter hyperintensity (WMH) volume, covert brain infarcts, hippocampal volume, and total cerebral brain volume were quantified. Results Baseline measures of WMH and hippocampal volume were associated with MCI status cross-sectionally and also with conversion from normal cognition to MCI at 6.5-year follow-up. Annualized change rates in total cerebral brain volume and hippocampal volume were associated with conversion from normal cognition to MCI to follow-up. Discussion Baseline WMH and hippocampal volume are markers that are both associated with conversion from normal cognition to MCI, highlighting the role of both vascular lesions and neurodegeneration in MCI. |
| Databáze: | OpenAIRE |
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