Cardiorespiratory activity of C-terminal pentapeptide of substance P in anaesthetized rats
| Autor: | Piotr Wojciechowski, Małgorzata Szereda-Przestaszewska, Andrzej W. Lipkowski |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Male
Pulmonary and Respiratory Medicine Bradycardia medicine.medical_specialty Time Factors Respiratory rate Physiology Blood Pressure Substance P Vagotomy 030226 pharmacology & pharmacy Pentapeptide repeat 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Respiratory Rate Heart Rate Internal medicine Tidal Volume medicine Animals Anesthesia Rats Wistar Respiratory system Tidal volume Analysis of Variance Chemistry Respiration General Neuroscience Peptide Fragments Rats Endocrinology Breathing medicine.symptom 030217 neurology & neurosurgery Respiratory minute volume |
| Zdroj: | Respiratory Physiology & Neurobiology. 233:7-13 |
| ISSN: | 1569-9048 |
| DOI: | 10.1016/j.resp.2016.07.006 |
| Popis: | Experiments were performed in anaesthetized, spontaneously breathing rats to: (1) analyse the respiratory and cardiovascular effects of C-terminal fragment of substance P (AWL2077) as referred to those exerted by the parent undecapeptide, (2) determine the involvement of lung vagal afferents to these responses. Each peptide was injected intravenously at a dose of 0.3μmol/kg into neurally intact or midcervically vagotomized rats. Administration of both compounds decreased tidal volume, minute ventilation, mean arterial blood pressure and heart rate, showing stimulatory (SP) and depressive (AWL2077) effects on the rate of breathing. Midcervical vagotomy reversed (post-SP) and precluded (post-AWL2077) respiratory rate responses and eliminated bradycardia evoked by both peptides. These findings indicate that the examined C-terminal pentapeptide was convergent with, but less potent than substance P in central depression of tidal volume and displayed divergence in the peripheral effect on respiratory timing. |
| Databáze: | OpenAIRE |
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