Salviachinensines A–F, Antiproliferative Phenolic Derivatives from the Chinese Medicinal Plant Salvia chinensis
| Autor: | Wu Hong, Qingsong Liu, Li Xixiang, Jing Liu, Zhenquan Hu, Aoli Wang, Qi Wang, Shugeng Cao |
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| Rok vydání: | 2018 |
| Předmět: |
Stereochemistry
Pharmaceutical Science 010402 general chemistry 01 natural sciences Chemical synthesis Analytical Chemistry chemistry.chemical_compound Phenols Cell Line Tumor Drug Discovery Humans Salvia Medicine Chinese Traditional Cell Proliferation Pharmacology Plants Medicinal biology Plant Extracts 010405 organic chemistry Chemistry Organic Chemistry Phenolic acid Nuclear magnetic resonance spectroscopy biology.organism_classification 0104 chemical sciences Complementary and alternative medicine Cell culture Molecular Medicine Salvia chinensis Epimer Isomerization Cis–trans isomerism |
| Zdroj: | Journal of Natural Products. 81:2531-2538 |
| ISSN: | 1520-6025 0163-3864 |
| Popis: | Six new phenolic acid derivatives, salviachinensines A-F (1-6), together with 14 known compounds (7-20) were isolated from the Chinese medicinal plant Salvia chinensis. The structures of salviachinensines A-F (1-6) were elucidated by NMR spectroscopy, bioinspired chemical synthesis, ECD analysis, and quantum chemical calculation methods. Compounds 2 and 3 are a pair of cis- trans isomers, and compounds 5 and 6 a pair of epimers. The solvent-induced isomerization of compounds 5 and 6 and the hypothetical biogenetic pathway of compounds 1-6, as well as the antiproliferative property and the ability of 1 to induce apoptosis and arrest cell cycle progression of MOLM-13 cells, were also investigated. |
| Databáze: | OpenAIRE |
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