Onset of connective tissue disease following anti-PD1/PD-L1 cancer immunotherapy
| Autor: | Pascale Chrétien, Xavier Mariette, Jean-Marie Michot, Sébastien Le Burel, Laurence Albiges, Anne-Laure Voisin, Stéphane Champiat, Emilie Routier, Sandrine Aspeslagh, Olivier Lambotte, Tali-Anne Szwebel |
|---|---|
| Přispěvatelé: | Medical Oncology, Laboratory for Medical and Molecular Oncology |
| Rok vydání: | 2017 |
| Předmět: |
Antineoplastic Agents
Immunological/adverse effects Male medicine.medical_specialty Immunology Autoimmunity General Biochemistry Genetics and Molecular Biology Connective Tissue Diseases/chemically induced Autoimmune Diseases 03 medical and health sciences Antineoplastic Agents Immunological 0302 clinical medicine Rheumatology Neoplasms medicine Humans Immunology and Allergy Sjøgren's Syndrome Prospective Studies Registries Connective Tissue Diseases Adverse effect Prospective cohort study Cryoglobulinemic vasculitis Myositis Aged Autoantibodies 030203 arthritis & rheumatology Biochemistry Genetics and Molecular Biology(all) business.industry Autoantibody Cancer Middle Aged medicine.disease Connective tissue disease Dermatology Neoplasms/drug therapy Treatment 030220 oncology & carcinogenesis Female Autoantibodies/blood business Complication |
| Zdroj: | Annals of the Rheumatic Diseases. 77:468-470 |
| ISSN: | 1468-2060 0003-4967 |
| DOI: | 10.1136/annrheumdis-2016-210820 |
| Popis: | Although treatment with immune checkpoint inhibitors (ICIs) is associated with better survival in many cancer settings, these therapeutics can induce immune-related adverse events (IrAEs).1 ,2 REISAMICi is a French, prospective, multicentre, academic registry sponsored by the Gustave Roussy Institute cancer centre. The objective is to better detect, document and manage IrAEs. Connective tissue diseases (CTD) have not previously been reported in patients treated with anti-PD1/PDL-1 agents. The REISAMIC registry was screened for reports of CTD. Of the 447 patients supervised in the REISAMIC registry, three have developed CTD: two cases of Sjogren's syndrome and one case of cryoglobulinemic vasculitis as a complication of suspected Sjogren's syndrome (table 1). A case of ANA+ myositis registered in REISAMIC by another investigating centre … |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|