Genetic ablation of sfrp4 in mice does not affect serum phosphate homeostasis
| Autor: | Shany Koren, Quan Yuan, Roland Baron, Marta Christov, Beate Lanske |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
Fibroblast growth factor 23
Male medicine.medical_specialty Mice 129 Strain Time Factors Blotting Western Biology Fibroblast growth factor urologic and male genital diseases Sodium-Phosphate Cotransporter Proteins Type IIa Phosphates chemistry.chemical_compound Mice Endocrinology Internal medicine Proto-Oncogene Proteins medicine Animals Homeostasis Klotho Klotho Proteins Gene knockout Glucuronidase Mice Knockout Reabsorption Renal-Cardiac-Vascular Phosphate female genital diseases and pregnancy complications Fibroblast Growth Factors Mice Inbred C57BL stomatognathic diseases Fibroblast Growth Factor-23 Phenotype chemistry Calcium Female SFRP4 |
| Zdroj: | Endocrinology. 152(5) |
| ISSN: | 1945-7170 |
| Popis: | Serum phosphate levels are regulated by PTH and the fibroblast growth factor 23 (Fgf23)/Klotho endocrine system, which both affect expression of Npt2a and thus the apical reabsorption of phosphate in the proximal renal tubules. In addition to Fgf23, secreted frizzled-related protein 4 (Sfrp4) has recently been implicated as an additional phosphate regulator in vivo and in vitro. Here we demonstrate that ablation of the Sfrp4 gene in mice does not lead to altered serum or urine phosphate levels. Furthermore, Sfrp4 is unable to compensate for the absence of Fgf23 or Klotho because double knockouts have a similar biochemical profile and phenotype as animals with ablation of Fgf23 or Klotho alone. Taken together, our data suggest that Sfrp4 does not contribute to the long-term regulation of serum phosphate levels in mice. |
| Databáze: | OpenAIRE |
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