Concise Total Synthesis of Herqulines B and C
| Autor: | Chi He, Thomas P. Stratton, Phil S. Baran |
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| Rok vydání: | 2018 |
| Předmět: |
Models
Molecular Chemistry Stereochemistry Molecular Conformation Total synthesis Stereoisomerism Chemistry Techniques Synthetic General Chemistry 010402 general chemistry complex mixtures 01 natural sciences Biochemistry Article Catalysis 0104 chemical sciences Reduction (complexity) chemistry.chemical_compound Alkaloids Colloid and Surface Chemistry Biosynthesis heterocyclic compounds Tyrosine Oxidation-Reduction |
| Zdroj: | Journal of the American Chemical Society. 141:29-32 |
| ISSN: | 1520-5126 0002-7863 |
| Popis: | A simple total synthesis of herqulines B and C is reported, modeled on the reductive biosynthesis reported previously by other researchers. Commencing from tyrosine, these alkaloids were fashioned through a dimerization, macrocyclization, and four consecutive reductions. Emerging from these studies are strategic insights on the synthesis of these strained alkaloids, as well as mild conditions for the exhaustive reduction of diketopiperizines. |
| Databáze: | OpenAIRE |
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