Transmission distortion ofBDNF variants to bipolar disorder type I patients from a south american population isolate
| Autor: | Andres Ruiz-Linares, Ibi Herzberg, Carlos López, Emily Kerr, Vicky Parra, Barbara Kremeyer, Jenny García, Carlos Palacio, Constanza Duque, Gabriel Bedoya, Jorge Ospina, Jorge Vega |
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| Rok vydání: | 2006 |
| Předmět: |
Male
Linkage disequilibrium Bipolar Disorder Population Mutation Missense Colombia Biology Polymorphism Single Nucleotide Linkage Disequilibrium Nuclear Family Cellular and Molecular Neuroscience Gene Frequency Polymorphism (computer science) medicine Humans Bipolar disorder Allele Dinucleotide Repeats education Allele frequency Alleles Genetics (clinical) Family Health Genetics education.field_of_study Brain-Derived Neurotrophic Factor Haplotype medicine.disease Psychiatry and Mental health Haplotypes Female rs6265 |
| Zdroj: | American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. :435-439 |
| ISSN: | 1552-485X 1552-4841 |
| Popis: | Recent reports have implicated polymorphisms in the brain derived neurotrophic factor (BDNF) gene region in the etiology of several psychiatric phenotypes, including bipolar disorder. Significant disease association has been reported for the G allele at SNP rs6265, which encodes for Valine at position 66 of BDNF (Val66Met), an apparently functional variant of this key BDNF. Here we examined a sample of 224 bipolar type I patients and available parents (comprising a total of 212 nuclear families) ascertained in a South American population isolate (Antioquia, Colombia). We tested for transmission distortion to bipolar patients of alleles at the rs6265 polymorphism and at a microsatellite marker 1.3 kb away from this SNP. Significant excess transmission of the rs6265 G allele to cases was observed (chi(2) = 10.77, d.f. = 1, P = 0.001). Two-locus haplotype analysis showed a significant global transmission distortion (chi(2) = 16.059, d.f. = 7, P = 0.025) with an excess transmission of a haplotype comprising the rs6265 G allele and microsatellite allele 227. These results are consistent with previous studies pointing to a role for BDNF in susceptibility to mood disorders. |
| Databáze: | OpenAIRE |
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