Degrees of functional connectome abnormality in disorders of consciousness
| Autor: | Elena I. Kremneva, S. N. Morozova, Dmitry O. Sinitsyn, Elizaveta G. Mochalova, Alexandra G. Poydasheva, Liudmila A. Legostaeva, Oksana G. Chervyakova, Michael A. Piradov, J. Ryabinkina, Natalia A. Suponeva |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Adolescent Brain activity and meditation media_common.quotation_subject 050105 experimental psychology Young Adult 03 medical and health sciences 0302 clinical medicine Level of consciousness Brain Injuries Traumatic Connectome medicine Humans 0501 psychology and cognitive sciences Radiology Nuclear Medicine and imaging Hypoxia Brain Research Articles Persistent vegetative state media_common Radiological and Ultrasound Technology Persistent Vegetative State 05 social sciences Brain Minimally conscious state Middle Aged medicine.disease Magnetic Resonance Imaging Neurology Consciousness Disorders Female Wakefulness Neurology (clinical) Nerve Net Anatomy Abnormality Consciousness Psychology Neuroscience 030217 neurology & neurosurgery |
| Zdroj: | Hum Brain Mapp |
| ISSN: | 1065-9471 |
| DOI: | 10.1002/hbm.24050 |
| Popis: | Understanding the neuronal basis of disorders of consciousness can help improve the accuracy of their diagnosis, indicate potential targets for therapeutic interventions, and provide insights into the organization of normal conscious information processing. Measurements of brain activity have been used to find associations of the levels of consciousness with brain complexity, topological features of functional connectomes, and disruption of resting‐state networks. However, obtainment of a detailed picture of activity patterns underlying the vegetative state/unresponsive wakefulness syndrome and the minimally conscious state remains a work in progress. We here aimed at finding the aspects of fMRI‐based functional connectivity that differentiate these states from each other and from the normal condition. A group of 22 patients was studied (9 minimally conscious state and 13 vegetative state/unresponsive wakefulness syndrome). Patients were shown to have reduced connectivity in most resting‐state networks and disrupted patterns of relative connection strengths as compared to healthy subjects. Differences between the unresponsive wakefulness syndrome and the minimally conscious state were found in the patterns formed by a relatively small number of strongest positive correlations selected by thresholding. These differences were captured by measures of functional connectivity disruption that integrate area‐specific abnormalities over the whole brain. The results suggest that the strong positive correlations between the functional activities of specific brain areas observed in healthy individuals may be critical for consciousness and be an important target of disruption in disorders of consciousness. |
| Databáze: | OpenAIRE |
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