Clinical significance of t(14; 18)-positive cells in the circulation of patients with stage III or IV follicular non-Hodgkin's lymphoma during first remission
| Autor: | L. C. J. Dorssers, M. B. Van't Veer, A. C. Lambrechts, P. E. Hupkes |
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| Rok vydání: | 1994 |
| Předmět: |
Cancer Research
medicine.medical_specialty Pathology Polymerase Chain Reaction Gastroenterology Translocation Genetic law.invention law Internal medicine Follicular phase medicine Humans Clinical significance Longitudinal Studies Stage (cooking) Lymphoma Follicular Polymerase chain reaction Chromosomes Human Pair 14 business.industry Remission Induction First remission Prognosis medicine.disease Lymphoma Follicular Non-Hodgkin's Lymphoma medicine.anatomical_structure Oncology Bone marrow Chromosomes Human Pair 18 business |
| Zdroj: | Journal of Clinical Oncology. 12:1541-1546 |
| ISSN: | 1527-7755 0732-183X |
| DOI: | 10.1200/jco.1994.12.8.1541 |
| Popis: | PURPOSE To evaluate polymerase chain reaction (PCR) analysis as a method for the detection of circulating lymphoma cells in patients with stage III and IV t(14; 18)-positive follicular Non-Hodgkin's lymphoma (NHL) in first remission in a longitudinal prospective study. PATIENTS AND METHODS Peripheral blood or bone marrow from eight patients with stage III and IV t(14; 18)-positive NHL was studied using PCR to detect the presence of t(14; 18)-positive cells in the circulation at different times during first remission. RESULTS In four of six patients with no clinical evidence of disease (NCED), t(14; 18)-positive cells were detectable in the circulation. In one of two patients with clinical evidence of disease (CED), no t(14; 18)-positive cells were found at the four different occasions tested during first remission. First-remission duration ranged from 17 to 81+ months. The duration from the first PCR determination in remission until first relapse or the end of the observation period ranged from 10 to 37+ months. CONCLUSION In patients with t(14; 18)-positive follicular NHL stage III and IV, treated with conventional remission induction therapy, the presence or absence of t(14; 18)-positive cells in the circulation shows no obvious correlation with the clinical remission status and the remission duration. |
| Databáze: | OpenAIRE |
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