Over-Dose Lithium Toxicity as an Occlusive-like Syndrome in Rats and Gastric Pentadecapeptide BPC 157
| Autor: | Ivan Barisic, Tatjana Orct, Danijela Kolenc, Predrag Sikiric, Hrvoje Vranes, Eva Lovric, Darija Muzinic, Sanja Strbe, Sven Seiwerth, Slaven Gojkovic, Zoran Zoričić, Jakša Vukojević, Anita Škrtić, Darko Marčinko, Dean Strinic, Igor Filipčić, Spomenko Ilic, Alenka Boban Blagaic, Helena Zizek, Ivan Krezic |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Lithium (medication) QH301-705.5 Medicine (miscellaneous) Infarction General Biochemistry Genetics and Molecular Biology Article occlusive-like syndrome Internal medicine Edema medicine Superior mesenteric vein Biology (General) business.industry medicine.disease Thrombosis gastric pentadecapeptide BPC 157 rats Venous thrombosis lithium toxicity Cardiology Portal hypertension medicine.symptom business Superior sagittal sinus medicine.drug |
| Zdroj: | Biomedicines Volume 9 Issue 11 Biomedicines, Vol 9, Iss 1506, p 1506 (2021) |
| ISSN: | 2227-9059 |
| Popis: | Due to endothelial impairment, high-dose lithium may produce an occlusive-like syndrome, comparable to permanent occlusion of major vessel-induced syndromes in rats intracranial, portal, and caval hypertension, and aortal hypotension multi-organ dysfunction syndrome brain, heart, lung, liver, kidney, and gastrointestinal lesions arterial and venous thrombosis and tissue oxidative stress. Stable gastric pentadecapeptide BPC 157 may be a means of therapy via activating loops (bypassing vessel occlusion) and counteracting major occlusion syndromes. Recently, BPC 157 counteracted the lithium sulfate regimen in rats (500 mg/kg/day, ip, for 3 days, with assessment at 210 min after each administration of lithium) and its severe syndrome (muscular weakness and prostration, reduced muscle fibers, myocardial infarction, and edema of various brain areas). Subsequently, BPC 157 also counteracted the lithium-induced occlusive-like syndrome rapidly counteracted brain swelling and intracranial (superior sagittal sinus) hypertension, portal hypertension, and aortal hypotension, which otherwise would persist counteracted vessel failure abrogated congestion of the inferior caval and superior mesenteric veins reversed azygos vein failure and mitigated thrombosis (superior mesenteric vein and artery), congestion of the stomach, and major hemorrhagic lesions. Both regimens of BPC 157 administration also counteracted the previously described muscular weakness and prostration (as shown in microscopic and ECG recordings), myocardial congestion and infarction, in addition to edema and lesions in various brain areas marked dilatation and central venous congestion in the liver large areas of congestion and hemorrhage in the lung and degeneration of proximal and distal tubules with cytoplasmic vacuolization in the kidney, attenuating oxidative stress. Thus, BPC 157 therapy overwhelmed high-dose lithium intoxication in rats. |
| Databáze: | OpenAIRE |
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