Sustained upregulation of widespread hippocampal–neocortical coupling following memory encoding
| Autor: | Line Folvik, Markus H Sneve, Hedda T Ness, Didac Vidal-Piñeiro, Liisa Raud, Oliver M Geier, Kristine B Walhovd, Anders M Fjell |
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| Rok vydání: | 2022 |
| Předmět: | |
| Zdroj: | Cerebral Cortex. 33:4844-4858 |
| ISSN: | 1460-2199 1047-3211 |
| DOI: | 10.1093/cercor/bhac384 |
| Popis: | Systems consolidation of new experiences into lasting episodic memories involves hippocampal–neocortical interactions. Evidence of this process is already observed during early post-encoding rest periods, both as increased hippocampal coupling with task-relevant perceptual regions and reactivation of stimulus-specific patterns following intensive encoding tasks. We investigate the spatial and temporal characteristics of these hippocampally anchored post-encoding neocortical modulations. Eighty-nine adults participated in an experiment consisting of interleaved memory task- and resting-state periods. We observed increased post-encoding functional connectivity between hippocampus and individually localized neocortical regions responsive to stimuli encountered during memory encoding. Post-encoding modulations were manifested as a nearly system-wide upregulation in hippocampal coupling with all major functional networks. The configuration of these extensive modulations resembled hippocampal–neocortical interaction patterns estimated from active encoding operations, suggesting hippocampal post-encoding involvement exceeds perceptual aspects. Reinstatement of encoding patterns was not observed in resting-state scans collected 12 h later, nor when using other candidate seed regions. The similarity in hippocampal functional coupling between online memory encoding and offline post-encoding rest suggests reactivation in humans involves a spectrum of cognitive processes engaged during the experience of an event. There were no age effects, suggesting that upregulation of hippocampal–neocortical connectivity represents a general phenomenon seen across the adult lifespan. |
| Databáze: | OpenAIRE |
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