Blood Serum Levels of Proinflammatory Cytokines (IL-1β, IL-6, TNFα, IL-8, IL-12p70, and IFNγ) in Patients with Uterine Myoma

Autor:	Prokof'ev Vf, A V Shevchenko, T I Dergacheva, A. M. Novikov, Vladimir I. Konenkov, N B Orlov, E. G. Koroleva
Rok vydání:	2018
Předmět:	Adult medicine.medical_specialty Angiogenesis Interleukin-1beta Gene Expression Inflammation General Biochemistry Genetics and Molecular Biology Proinflammatory cytokine Interferon-gamma 03 medical and health sciences 0302 clinical medicine Blood serum Internal medicine Uterine Myomectomy Humans Medicine Interleukin 8 Uterine myoma Interleukin 6 030219 obstetrics & reproductive medicine Leiomyoma biology Interleukin-6 Tumor Necrosis Factor-alpha business.industry Interleukin-8 Uterus General Medicine Middle Aged Interleukin-12 Endocrinology 030220 oncology & carcinogenesis Uterine Neoplasms biology.protein Female Tumor necrosis factor alpha medicine.symptom business
Zdroj:	Bulletin of Experimental Biology and Medicine. 165:698-701
ISSN:	1573-8221 0007-4888
DOI:	10.1007/s10517-018-4245-0
Popis:	We analyzed cytokine profile in blood serum of patients with uterine myoma and revealed significantly reduced level of IFNγ and a tendency towards a decrease in the levels of IL-1β and TNFα; the levels of IL-6, IL-8, and IL-12p70 did not differ from those in healthy women. The drop in the concentrations of factors responsible for inflammation and angiogenesis in tissues are unfavorable for proliferation and differentiation of the uterine tissues.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6f0e7c11610dfbc6d789449c4d8cd33 https://doi.org/10.1007/s10517-018-4245-0 Zobrazit plný text záznamu Full text from SpringerLink