Synthesis and preliminary pharmacological evaluation of thiophene analogues of viloxazine as potentialantidepressant drugs

Autor:	José Antonio Martín Conde, C. Corral, V. Darias, C.C. Sánchez-Mateo, Ignacio Manzanares, María A. Expo'sito-Orta, J. Lissavetzky
Rok vydání:	1999
Předmět:	Male Imipramine Apomorphine medicine.drug_class Stereochemistry Tetrabenazine Clinical Biochemistry Pharmaceutical Science Hypothermia Biochemistry Chemical synthesis Viloxazine 5-Hydroxytryptophan Lethal Dose 50 Mice Structure-Activity Relationship chemistry.chemical_compound Drug Discovery medicine Thiophene Animals Blepharoptosis Pentobarbital Molecular Biology Movement Disorders Dose-Response Relationship Drug Organic Chemistry Thiophene derivatives Combinatorial chemistry Antidepressive Agents chemistry Sedative Molecular Medicine Female Sleep medicine.drug
Zdroj:	Bioorganic & Medicinal Chemistry. 7:1349-1359
ISSN:	0968-0896
Popis:	A series of eight thienyloxymethylmorpholines, thiophene analogues of viloxazine, have been synthesized by three different routes. The preliminary pharmacological evaluation of this series shows antidepressant properties on the mice models used with a light sedative action. The structure-activity relationship is established in a first approximation.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6f0aa087a0ba098cf9302b6d34442f7 https://doi.org/10.1016/s0968-0896(99)00070-x Zobrazit plný text záznamu Full Text from ScienceDirect