New solid tumor targets for therapeutic monoclonal antibodies
| Autor: | Jackie Papkoff |
|---|---|
| Rok vydání: | 2007 |
| Předmět: |
Antibodies
Neoplasm medicine.drug_class Clinical Biochemistry Monoclonal antibody Metastasis Mice Drug Delivery Systems Antigens Neoplasm Neoplasms Drug Discovery medicine Animals Humans Tumor growth Neoplasm Metastasis Solid tumor Target antigen Mice Knockout Pharmacology biology Antibodies Monoclonal Cancer medicine.disease Neoplasm Proteins Cell Transformation Neoplastic Organ Specificity Antigens Surface Immunology biology.protein Molecular Medicine Immunotherapy Drug Screening Assays Antitumor Signal transduction Antibody |
| Zdroj: | Expert Opinion on Therapeutic Targets. 11:585-588 |
| ISSN: | 1744-7631 1472-8222 |
| DOI: | 10.1517/14728222.11.5.585 |
| Popis: | Monoclonal antibodies are a rapidly growing class of drugs used for therapy of human cancers and other diseases. They can be used effectively to target tumor-specific molecules and thereby modulate key signaling pathways that play a role in tumor growth, survival and metastasis. Clinical success of novel antibodies has stimulated great interest in the promise of antibody therapeutics for cancer. In this editorial, the author describes three key characteristics that define an ideal target antigen for a therapeutic antibody. |
| Databáze: | OpenAIRE |
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