Age-related changes in Arc transcription and DNA methylation within the hippocampus
| Autor: | J.D. Sweatt, Monica K. Chawla, Paul F. Worley, Tania L. Roth, Carol A. Barnes, Lan T. Hoang, Eric D. Roth, Farah D. Lubin, M.R. Penner |
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| Rok vydání: | 2009 |
| Předmět: |
Male
Aging Transcription Genetic Molecular Sequence Data Spatial Behavior Nerve Tissue Proteins Biology Hippocampus Article Transcription (biology) Animals Epigenetics Memory Disorders Base Sequence General Neuroscience Dentate gyrus Methylation DNA Methylation Rats Inbred F344 Rats Cytoskeletal Proteins nervous system DNA methylation Synaptic plasticity Memory consolidation Neurology (clinical) Geriatrics and Gerontology Immediate early gene Neuroscience Developmental Biology |
| Zdroj: | Neurobiology of aging. 32(12) |
| ISSN: | 1558-1497 |
| Popis: | The transcription of genes that support memory processes are likely to be impacted by the normal aging process. Because Arc is necessary for memory consolidation and enduring synaptic plasticity, we examined Arc transcription within the aged hippocampus. Here, we report that Arc transcription is reduced within the aged hippocampus compared to the adult hippocampus during both “off line” periods of rest, and following spatial behavior. This reduction is observed within ensembles of CA1 “place cells”, which make less mRNA per cell, and in the dentate gyrus (DG) where fewer granule cells are activated by behavior. In addition, we present data suggesting that aberrant changes in methylation of the Arc gene may be responsible for age-related decreases in Arc transcription within CA1 and the DG. Given that Arc is necessary for normal memory function, these subregion-specific epigenetic and transcriptional changes may result in less efficient memory storage and retrieval during aging. |
| Databáze: | OpenAIRE |
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