Lung Perfusion Scintigraphy Early After COVID-19: A Single-Center Retrospective Study
| Autor: | Tinu Lukose, Ranganath T G, Sajal De, Mudalsha Ravina, Dibakar Sahu |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Male
medicine.medical_specialty Perfusion Imaging Perfusion scanning Imaging D-dimer medicine Humans Radiology Nuclear Medicine and imaging Lung Retrospective Studies PET-CT Radiological and Ultrasound Technology medicine.diagnostic_test business.industry SARS-CoV-2 COVID-19 Retrospective cohort study General Medicine Odds ratio medicine.disease Pulmonary embolism early–post-COVID-19 patients Perfusion novel coronavirus disease 2019 lung perfusion scan Female Radiology business Pulmonary Embolism Emission computed tomography |
| Zdroj: | Journal of Nuclear Medicine Technology |
| ISSN: | 1535-5675 0091-4916 |
| Popis: | Visual Abstract The incidence of thromboembolic complications in coronavirus disease 2019 (COVID-19) infection is well recognized. The present study retrospectively evaluated the type and prevalence of lung perfusion defects in early–post-COVID-19 patients with hypoxia and was aimed to identify the risk factors for mismatched perfusion defects. Methods: We analyzed SPECT/CT images of 54 early–post-COVID-19 patients (44 men and 10 women). Logistic regression analysis was used to examine the risk. Results: The mean age of the study population was 55.4 y (range, 34–76 y). All received prophylactic anticoagulation from the day of hospitalization to the date of perfusion scanning. The median interval between COVID-19–positive reports and lung perfusion scanning was 22 d. Lung perfusion defects (of any type) were observed in most (87%). Twenty-three subjects (42.6%) had mismatched perfusion defects. Mismatched perfusion defects were segmental in 14 subjects (25.9%) and subsegmental in 11 (20.4%). Higher age was a risk factor for mismatched perfusion defects (odds ratio, 1.06; 95% CI, 0.99–1.13; P = 0.06). Subjects with a serum D-dimer level of at least 2,500 ng/mL on the day before the scan were not at higher risk for having mismatched perfusion defects (odds ratio, 1.14; 95% CI, 0.34–3.9; P = 0.83). Conclusion: Despite prophylactic anticoagulation, mismatched perfusion defects suggestive of pulmonary thromboembolism were observed. Serum D-dimer level in patients early after COVID-19 is a poor predictor of mismatched perfusion defects. Confirmed evidence of pulmonary embolism by imaging studies should support the decision to extend anticoagulant prophylaxis in post-COVID-19 patients. |
| Databáze: | OpenAIRE |
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