The synthetic GLP-I receptor agonist, exenatide, reduces intimal hyperplasia in insulin resistant rats

Autor: Jennifer McGee, Vivian Fonseca, David B. Casey, Subramanyam N. Murthy, Rose-Claire St. Hilaire, Adeleke M. Badejo, Dennis B. McNamara, Philip J. Kadowitz
Rok vydání: 2010
Předmět:
Zdroj: Diabetes and Vascular Disease Research. 7:138-144
ISSN: 1752-8984
1479-1641
DOI: 10.1177/1479164109360269
Popis: We studied the effect of a synthetic GLP-1 receptor agonist, exenatide, a drug approved for the treatment of type 2 diabetes, on the recovery from vascular injury in Zucker (non-diabetic) fatty rats. Exenatide 5.0 µg/kg per day or saline was administered for seven days before, and 21 days after balloon catheter mediated carotid injury. A pair feeding experiment helped differentiate between the drug itself and the known effects of the drug on decreased food intake. Body weight and glucose (weekly), carotid artery I/M ratio, aortic protein eNOS and NFκB-p65 were measured. Body weight gain in exenatide rats was significantly lower (53±5 vs. 89±8 g) than controls. Blood glucose did not change significantly. The I/M ratio in the exenatide group was 0.2±0.1 vs. 0.9±0.1 in controls ( p
Databáze: OpenAIRE
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