In vitrotoxicity of trichothecenes on human haematopoietic progenitors
| Autor: | R. Fuselier, D. Thouvenot, Dominique Parent-Massin |
|---|---|
| Rok vydání: | 1994 |
| Předmět: |
Cell Survival
Health Toxicology and Mutagenesis Trichothecene Biology Toxicology medicine.disease_cause Diacetoxyscirpenol chemistry.chemical_compound medicine Humans Macrophage Cytotoxic T cell Progenitor cell Cells Cultured Toxin Macrophages Public Health Environmental and Occupational Health General Chemistry Hematopoietic Stem Cells Molecular biology T-2 Toxin Haematopoiesis chemistry Chemistry (miscellaneous) Cell culture Immunology Trichothecenes Granulocytes Food Science |
| Zdroj: | Food Additives and Contaminants. 11:441-447 |
| ISSN: | 0265-203X |
| Popis: | The culture of human haematopoietic progenitors, Colony-Forming-Unit Granulocyte and Macrophage (CFU-GM), has been performed in the presence of four trichothecenes, T-2 toxin, HT-2 toxin, diacetoxyscirpenol (DAS), and deoxynivalenol (DON). Our results showed that trichothecenes were cytotoxic for human haematopoietic progenitors. This work and the analysis of results described in the literature allowed us to propose that the haematologic lesions observed during human intoxication could be due to a destruction of haematopoietic progenitors such as granulocytic and macrophage colony-forming cells. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|