Lipid Peroxidation in Brain or Spinal Cord Mitochondria After Injury
| Autor: | Indrapal N. Singh, Jeffrey M. Bosken, Juan A. Wang, Edward D. Hall |
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| Jazyk: | angličtina |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Physiology Mitochondrion medicine.disease_cause Neuroprotection Article Lipid peroxidation 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine Animals Humans Reactive nitrogen species Spinal Cord Injuries Chemistry Nervous tissue Brain Cell Biology Spine Cell biology Mitochondria 030104 developmental biology medicine.anatomical_structure Biochemistry Mitochondrial permeability transition pore Brain Injuries Lipid Peroxidation 030217 neurology & neurosurgery Oxidative stress Peroxynitrite |
| Popis: | Extensive evidence has demonstrated an important role of oxygen radical formation (i.e., oxidative stress) as a mediator of the secondary injury process that occurs following primary mechanical injury to the brain or spinal cord. The predominant form of oxygen radical-induced oxidative damage that occurs in injured nervous tissue is lipid peroxidation (LP). Much of the oxidative stress in injured nerve cells initially begins in mitochondria via the generation of the reactive nitrogen species peroxynitrite (PN) which then can generate multiple highly reactive free radicals including nitrogen dioxide (•NO2), hydroxyl radical (•OH) and carbonate radical (•CO3). Each can readily induce LP within the phospholipid membranes of the mitochondrion leading to respiratory dysfunction, calcium buffering impairment, mitochondrial permeability transition and cell death. Validation of the role of LP in central nervous system secondary injury has been provided by the mitochondrial and neuroprotective effects of multiple antioxidant agents which are briefly reviewed. |
| Databáze: | OpenAIRE |
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