Acoustofluidic Scanning Nanoscope with High Resolution and Large Field of View
| Autor: | Hunter Bachman, Zhenhua Tian, Joseph Rufo, Geonsoo Jin, Tony Jun Huang, Ty Downing Naquin, Serena Hou, Chenglong Zhao |
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| Rok vydání: | 2020 |
| Předmět: |
Physics
Large field of view Microscope Atomic de Broglie microscope business.industry Research areas Resolution (electron density) ComputingMethodologies_IMAGEPROCESSINGANDCOMPUTERVISION General Engineering General Physics and Astronomy High resolution Image processing 02 engineering and technology 010402 general chemistry 021001 nanoscience & nanotechnology 01 natural sciences Article 0104 chemical sciences law.invention Acoustic streaming Optics law General Materials Science 0210 nano-technology business |
| Zdroj: | ACS Nano |
| ISSN: | 1936-086X 1936-0851 |
| Popis: | Optical imaging with nanoscale resolution and a large field of view is highly desirable in many research areas. Unfortunately, it is challenging to achieve these two features simultaneously while using a conventional microscope. An objective lens with a low numerical aperture (NA) has a large field of view but poor resolution. In contrast, a high NA objective lens will have a higher resolution but reduced field of view. In an effort to close the gap between these trade-offs, we introduce an acoustofluidic scanning nanoscope (AS-nanoscope) that can simultaneously achieve high resolution with a large field of view. The AS-nanoscope relies on acoustofluidic-assisted scanning of multiple microsized particles. A scanned 2D image is then compiled by processing the microparticle images using an automated big-data image algorithm. The AS-nanoscope has the potential to be integrated into a conventional microscope or could serve as a stand-alone instrument for a wide range of applications where both high resolution and large field of view are required. |
| Databáze: | OpenAIRE |
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