Can grape polyphenols affect glycation markers? A systematic review
| Autor: | Olívia Gonçalves Leão Coelho, Priscila Vaz de Melo Ribeiro, Rita de Cássia Gonçalves Alfenas |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Antioxidant
food.ingredient business.industry medicine.medical_treatment fungi Methylglyoxal food and beverages General Medicine Pharmacology Resveratrol Industrial and Manufacturing Engineering RAGE (receptor) chemistry.chemical_compound food Proanthocyanidin chemistry Polyphenol Glycation Grape seed extract medicine business Food Science |
| Zdroj: | Critical Reviews in Food Science and Nutrition. 63:1208-1218 |
| ISSN: | 1549-7852 1040-8398 |
| DOI: | 10.1080/10408398.2021.1962796 |
| Popis: | Advanced glycation end-products (AGEs) favor inflammation and oxidative stress, playing a role in chronic diseases pathogenesis. Grape polyphenols exert antiglycative and antioxidant effects which may contribute to prevent chronic diseases. However, clinical evidence of grape polyphenols on chronic disease prevention and treatment by glycation markers modulation are limited. Therefore, we aimed to critically analyze studies about that topic to investigate the antiglycative power of dietary grape polyphenol, and to explore the molecular mechanism involved. This systematic review was conducted and reported according to PRISMA guidelines. The following search terms were used: "grape", "extract", "grape seed extract", "grape skin extract", "polyphenol extract", "grape polyphenol(s)", "grape juice", "resveratrol", "quercetin", "catechin", "epicatechin", "procyanidin(s)", and "anthocyanin(s)". Seven studies were included. Glycated hemoglobin was not affected. The interventions duration may not have been enough to detect changes. Grape polyphenols reduced fructosamine and methylglyoxal (MGO) concentrations, and increased endogenous secretory RAGE (esRAGE) gene expression but did not affect the serum concentration. Resveratrol antiglycative effects are mainly due its ability to trap MGO and downregulate RAGE. In conclusion, grape polyphenols may have a positive impact on early glycation products, AGEs and esRAGE. Future studies are needed to explore how they modulate AGEs and receptors in chronic diseases. |
| Databáze: | OpenAIRE |
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