Usefulness of metyrapone treatment to suppress cancer metastasis facilitated by surgical stress
| Autor: | Masaaki Deguchi, Yoshiaki Isobe, Shigeru Matsukawa, Gizo Nakagawara, Akio Yamaguchi |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
medicine.medical_specialty
Lung Neoplasms Surgical stress medicine.medical_treatment Apoptosis Thymus Gland Metastasis Rats Sprague-Dawley Leukocyte Count Stress Physiological Internal medicine Animals Medicine Lymphocyte Count Neoplasm Metastasis Dexamethasone Chemotherapy Metyrapone business.industry Adrenalectomy Respiratory disease Mammary Neoplasms Experimental Cancer medicine.disease Rats Endocrinology Surgical Procedures Operative Female Surgery Corticosterone business medicine.drug |
| Zdroj: | Surgery. 123:440-449 |
| ISSN: | 0039-6060 |
| DOI: | 10.1016/s0039-6060(98)70166-7 |
| Popis: | Background: One causative factor of tumor metastasis enhanced by surgical stress is thought to be hypersecretion of endogenous glucocorticoids. This study evaluated the effectiveness of metyrapone treatment and adrenalectomy in preventing the harmful effects of glucocorticoids in the enhancement of tumor metastasis resulting from surgical stress. Methods: The effect of dexamethasone on pulmonary metastasis of MRMT-1 cells and on the number of peripheral lymphocytes was evaluated in rats. To evaluate the suppressive effect of adrenalectomy and metyrapone treatment on operation-induced enhancement of metastasis, several parameters such as induction of pulmonary metastasis, serum corticosterone levels, and the number of blood lymphocytes and apoptotic thymocytes were determined. Results: With dexamethasone treatment, the number of peripheral lymphocytes rapidly decreased; in contrast, pulmonary metastasis increased. The serum corticosterone level was doubled at 1 hour, apoptotic thymocyte numbers were increased about sevenfold at 3 hours and about fourfold at 6 hours, and blood lymphocyte numbers were decreased at 3 hours after laparotomy, which facilitated about a 10-fold increase in the pulmonary metastasis. These changes were almost completely suppressed by preoperative adrenalectomy and metyrapone treatment. Conclusions: Preoperative metyrapone treatment, which suppresses hypersecretion of endogenous glucocorticoids as a result of operation, modulates the enhancement of cancer metastases and may be an effective treatment. (Surgery 1998;123:440-9.) |
| Databáze: | OpenAIRE |
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