Macrophage ferroportin is essential for stromal cell proliferation in wound healing
| Autor: | Massimo Locati, Gaetano Cairo, Elena Gammella, Paolo Buratti, Stefania Recalcati, Andrea Doni, Achille Anselmo |
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| Rok vydání: | 2018 |
| Předmět: |
Stromal cell
Iron Ferroportin Mice Transgenic Iron metabolism & its Disorders Article Mice 03 medical and health sciences 0302 clinical medicine medicine Animals Cation Transport Proteins Cell Proliferation Skin Wound Healing integumentary system biology Chemistry Cell growth Macrophages Granulation tissue Epithelial Cells Hematology Hair follicle medicine.disease Cell biology medicine.anatomical_structure Hair loss biology.protein Erythropoiesis Stromal Cells Wound healing 030215 immunology |
| Zdroj: | Haematologica |
| ISSN: | 1592-8721 0390-6078 |
| DOI: | 10.3324/haematol.2018.197517 |
| Popis: | Iron recycling by macrophages is essential for erythropoiesis, but may also be relevant for iron redistribution to neighboring cells at the local tissue level. Using mice with iron retention in macrophages due to targeted inactivation of the iron exporter ferroportin, we investigated the role of macrophage iron release in hair follicle cycling and wound healing, a complex process leading to major clinical problems, if impaired. Genetic deletion of ferroportin in macrophages resulted in iron deficiency and decreased proliferation in epithelial cells, which consequently impaired hair follicle growth and caused transient alopecia. Hair loss was not related to systemic iron deficiency or anemia, thus indicating the necessity of local iron release from macrophages. Inactivation of macrophage ferroportin also led to delayed skin wound healing with defective granulation tissue formation and diminished fibroplasia. Iron retention in macrophages had no impact on the inflammatory processes accompanying wound healing, but affected stromal cell proliferation, blood and lymphatic vessel formation, and fibrogenesis. Our findings reveal that iron/ferroportin plays a largely underestimated role in macrophage trophic function in skin homeostasis and repair. |
| Databáze: | OpenAIRE |
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