4'-N-methyl-5'-hydroxystaurosporine and 5'-hydroxystaurosporine, new indolocarbazole alkaloids from a marine Micromonospora sp. strain

Autor:	Julia Perez Baz, José L. Fernández Puentes, Dolores Garcia Gravalos, Librada M. Canedo Hernandez, Jesus Angel de la Fuente Blanco, Francisco Romero Millan, Rosa Isabel Fernández-Chimeno, Fernando Espliego Vazquez
Rok vydání:	2000
Předmět:	Indoles Magnetic Resonance Spectroscopy Stereochemistry Carbazoles Antineoplastic Agents Indolocarbazole Micromonospora chemistry.chemical_compound Inhibitory Concentration 50 Mice Alkaloids Drug Discovery medicine Tumor Cells Cultured Staurosporine Animals Humans Pharmacology Strain (chemistry) biology Alkaloid biology.organism_classification Micromonosporaceae chemistry Biochemistry Fermentation Actinomycetales Drug Screening Assays Antitumor Water Microbiology HT29 Cells medicine.drug
Zdroj:	The Journal of antibiotics. 53(9)
ISSN:	0021-8820
Popis:	Two new indolocarbazole alkaloids, 4'-N-methyl-5'-hydroxystaurosporine (2) and 5'-hydroxystaurosporine (3), were isolated together with the known staurosporine (1) from the culture broth of a marine Micromonospora sp. (strain L-31-CLCO-002). The fermentation, structural data and cytotoxic activities of these compounds against various tumor cell lines are given.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a6dc7e66994c1a8e94a81ebf29c7d010 https://pubmed.ncbi.nlm.nih.gov/11099222 Zobrazit plný text záznamu