A study on clinical outcomes of combination of terlipressin and albumin in Hepatorenal Syndrome
| Autor: | O V Sudheer, Remya Reghu, Drishya Dev, Rakhi Krishna, Jina Raj, Sruthy C. Prasad |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Liver Cirrhosis
Male medicine.medical_specialty Cirrhosis Hepatorenal Syndrome India Kidney Kidney Function Tests Gastroenterology Tertiary Care Centers 03 medical and health sciences 0302 clinical medicine Fulminant hepatic failure Hepatorenal syndrome Recurrence Internal medicine Albumins medicine Humans Vasoconstrictor Agents In patient Prospective Studies Aged business.industry Albumin Middle Aged medicine.disease Treatment Outcome 030220 oncology & carcinogenesis Quality of Life 030211 gastroenterology & hepatology Drug Therapy Combination Female Terlipressin business medicine.drug |
| Zdroj: | Scandinavian journal of gastroenterology. 55(7) |
| ISSN: | 1502-7708 |
| Popis: | Hepatorenal Syndrome (HRS) is a reversible functional renal impairment that occurs in patients with advanced liver cirrhosis or those with fulminant hepatic failure.To evaluate the effect of terlipressin and albumin combination in various clinical outcomes in Hepatorenal Syndrome patientsIn the present study the mean age of patients was found to be 55.10 ± 9.35 years. Mean serum creatinine values were found to be reduced (1.22 ± 0.96) by 10th day in type 1 HRS which indicated improved renal function. Study patients showed a marked improvement in liver function throughout the observation period. 74% of patients did not have HRS recurrence and 79.48% of patients had completely relieved from HRS. Loose stool (14.2%) and hyponatremia (14.2%) were the prominent side effects of the therapy. The quality of life of patients also showed a statistically significant betterment in both physical and mental functioning.Our study concluded that terlipressin and albumin combination was safe and effective in successfully stabilising cirrhosis patients with Hepatorenal Syndrome and bridging eligible patients to liver transplantation by restoring the liver and renal function with minimal adverse effects. |
| Databáze: | OpenAIRE |
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