Non-carbapenem antimicrobial therapy in young infant with urinary tract infections caused by community-acquired extended-spectrum β-lactamase-producing Escherichia coli
Autor: | Seong Heon Kim, Kyo Jin Jo, Su Eun Park, Sukdong Yoo, Ji Yeon Song |
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Rok vydání: | 2021 |
Předmět: |
Carbapenem
medicine.medical_specialty medicine.medical_treatment Urinary system medicine.disease_cause Pediatrics beta-Lactamases RJ1-570 Urinary catheterization carbapenem Anti-Infective Agents Internal medicine Chart review Escherichia coli polycyclic compounds medicine Humans In patient Child Escherichia coli Infections Retrospective Studies business.industry Infant Newborn biochemical phenomena metabolism and nutrition extended-spectrum β-lactamase bacterial infections and mycoses Antimicrobial infant Anti-Bacterial Agents Community-Acquired Infections Urinary Tract Infections Pediatrics Perinatology and Child Health bacteria urinary tract infection business Urine sample medicine.drug |
Zdroj: | Pediatrics and Neonatology, Vol 62, Iss 3, Pp 271-277 (2021) |
ISSN: | 1875-9572 |
Popis: | Background The frequency of urinary tract infections (UTIs) caused by community-acquired extended-spectrum β-lactamase (CA-ESBL)-producing Enterobacteriaceae is increasing worldwide. Increased carbapenem use may lead to selection of carbapenem-resistant organisms, resulting in dire consequences for hospitals. We compared the outcomes of non-carbapenem antimicrobial therapy on UTIs caused by CA-ESBL-producing and non-producing Escherichia coli (E. coli) in infants younger than 6 months of age. Methods We conducted a retrospective chart review, from January 2010 to December 2018, in infants (0–6 months old) with diagnosed UTIs caused by CA-ESBL-producing and non-producing E. coli at the Pusan National University Children's Hospital. Chart reviews were completed for patients whose urine sample had been collected using urinary catheterization. We treated all patients using non-carbapenem antimicrobials. Two weeks after therapy completion, clinical states were evaluated. Results There were 105 and 582 patients diagnosed with UTIs caused by CA-ESBL-producing and non-producing E. coli, respectively. The mean age at diagnosis in ESBL and non-ESBL groups was 2.7 ± 1.6 and 2.8 ± 1.1 months (P = 0.711), respectively. There were no significant differences between ESBL and non-ESBL groups in the duration of fever (1.2 ± 0.5 and 1.2 ± 0.4 days, respectively, P = 0.761) or clinical cure states post therapy (101/105 and 567/582, respectively, P = 0.513). Conclusion This study found no significant differences in treatment outcomes between ESBL and non-ESBL groups treated with non-carbapenem antimicrobials. Therefore, initially administered non-carbapenem antimicrobials can be continued in patients with UTIs caused by CA-ESBL-producing E. coli who show clinical improvement. |
Databáze: | OpenAIRE |
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