Cardiovascular Effects of Ketanserin in the Treatment of Hypertension During Coronary Artery Bypass Surgery
| Autor: | Paul Späth, Josef A. Richter, Erwin Göb, Andreas Barankay |
|---|---|
| Rok vydání: | 1986 |
| Předmět: |
Adult
Male Extracorporeal Circulation medicine.medical_specialty Ketanserin Blood Pressure Coronary artery bypass surgery Piperidines Internal medicine medicine.artery medicine Humans Cardiac Output Coronary Artery Bypass Pulmonary wedge pressure Antihypertensive Agents Aged Pharmacology business.industry Extracorporeal circulation Hemodynamics Central venous pressure Stroke volume Middle Aged Blood pressure Hypertension Pulmonary artery Cardiology Vascular Resistance Cardiology and Cardiovascular Medicine business medicine.drug |
| Zdroj: | Journal of Cardiovascular Pharmacology. 8:109-115 |
| ISSN: | 0160-2446 |
| DOI: | 10.1097/00005344-198601000-00017 |
| Popis: | The cardiovascular effects of ketanserin (5-HT2-receptor antagonist with alpha 1-receptor blocking property) were studied during coronary artery surgery. Sixteen patients were anesthetized with flunitrazepamfentanyl-nitrous oxide-oxygen-pancuronium. Ketanserin (10 mg i.v.) was used to decrease elevated blood pressure unresponsive to deepening of anesthesia before extracorporeal circulation. Ketanserin caused a marked vasodilation in all patients, significant (p less than 0.05) decreases of systolic, diastolic, and mean arterial blood pressure, and of pulmonary artery pressure and pulmonary capillary wedge pressure. As a result, indirect indices of myocardial oxygen demand (rate-pressure product and "triple index") also decreased. Heart rate and right atrial pressure remained unchanged, while cardiac index and stroke volume index increased slightly. Ketanserin was found to be effective in the treatment of prebypass hypertension; the elevated blood pressure returned to normal; unwanted hypotension was not observed. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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