Physical exercise increases plasma concentrations of nicotine during treatment with a nicotine patch
| Autor: | Tor Ole Klemsdal, Knut Gjesdal, K. Zahlsen |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Adult
Male medicine.medical_specialty Nicotine Nicotine patch medicine.medical_treatment Hemodynamics Physical exercise Administration Cutaneous Dosage form Internal medicine Blood plasma medicine Humans Pharmacology (medical) Exercise Pharmacology Chemistry Blood flow Middle Aged Endocrinology Plasma concentration Female Skin Temperature medicine.drug Research Article |
| Zdroj: | British journal of clinical pharmacology. 39(6) |
| ISSN: | 0306-5251 |
| Popis: | The effect of physical exercise on plasma nicotine concentrations was studied in eight healthy subjects treated with a nicotine patch releasing 14 mg 24 h-1. After 11 h of patch application, plasma nicotine concentrations were measured before and after 20 min of moderate bicycle exercise, or 20 min of rest. Mean plasma nicotine concentration increased from 9.8 to 11.0 ng ml-1 (P = 0.015) during physical exercise, and fell non-significantly from 10.5 to 10.2 ng ml-1 during rest. The increase in plasma nicotine concentration during exercise is similar to that observed for transdermal nitroglycerin, and may be related to an exercise-induced increase in blood flow in the patch area. |
| Databáze: | OpenAIRE |
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