Salmon calcitonin nasal spray in the prevention of corticosteroid- induced osteoporosis
| Autor: | Mary J. Bell, Michael Gent, Bianchi F, P. Tugwell, Robin S. Roberts, G. L. Craig, William G. Bensen, E Themeles, M Gordon, Rolf J. Sebaldt, M. Steele, Jonathan D. Adachi, W C Sturtridge, Alfred Cividino |
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| Rok vydání: | 1997 |
| Předmět: |
Calcitonin
Male musculoskeletal diseases medicine.medical_specialty Bone disease medicine.drug_class medicine.medical_treatment Osteoporosis Lumbar vertebrae Gastroenterology Bone and Bones Polymyalgia rheumatica Absorptiometry Photon Double-Blind Method Rheumatology Bone Density Internal medicine Administration Inhalation medicine Humans Pharmacology (medical) Glucocorticoids Aged Bone mineral Analgesics Lumbar Vertebrae business.industry medicine.disease Surgery medicine.anatomical_structure Nasal spray Polymyalgia Rheumatica Prednisone Corticosteroid Female Safety business hormones hormone substitutes and hormone antagonists |
| Zdroj: | Rheumatology. 36:255-259 |
| ISSN: | 1462-0332 1462-0324 |
| DOI: | 10.1093/rheumatology/36.2.255 |
| Popis: | The objectives were to determine the efficacy and safety of nasal salmon calcitonin 200 IU daily in the prevention of corticosteroid-induced osteoporosis. A minimized, double-blind, placebo-controlled trial was carried out in corticosteroid-treated patients with polymyalgia rheumatica. The setting was a tertiary care university-affiliated hospital and a total of 31 patients were enrolled. The primary outcome measure was the percentage change in bone mineral density of the lumbar spine in the two treatment groups from baseline to 1 yr of follow-up. The mean +/- S.D. bone mineral density of the lumbar spine in the calcitonin-treated group decreased by 1.29 +/- 6.76% and in the placebo group by 4.95 +/- 3.50% after 12 months. The observed difference of 3.65 +/- 2.10% between groups is statistically significant (P < 0.05). Nasal salmon calcitonin prevented loss of bone in the lumbar spine as measured by dual-energy X-ray absorptiometry. |
| Databáze: | OpenAIRE |
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